Click Chemistry

Exatecan-2-(aminomethoxy)acetamide-Gly-Phe-Gly-Gly-PEG1-NHS ester functions as linker-payload conjugate featuring an NHS ester which can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. Exatecan-2-(aminomethoxy)acetamide-Gly may be employed as a payload in ADC research. The peptide linker is a cleavable linker that may be useful for drug delivery. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Bz-rA Phosphoramidite represents a TBDMS-protected nucleoside phosphoramidite, which can be used to create oligonucleotides. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Azide-PEG8-Val-Cit-PABC-Exatecan is a unique linker payload containing an azide handle for Copper-Catalyzed click chemistry with alkyne, DBCO, and BCN. The PEG8 chain improves hydrophilicity and helps fine-tune DMPK properties. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

BP Lipid 425 is a symmetric polar lipid featuring a two unsaturated oleic acid tails and useful maleimide-PEG4 linker. This compound may be used for bioconjugation and surface modification applications, or as a useful synthetic scaffold for novel lipids. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

NHS ester-Val-Cit-PAB-MMAE serves as a precursor of antibody-drug conjugates (ADCs). It contains a cathepsin-cleavable Val-Cit dipeptide and MMAE payload. The MMAE is a synthetic antineoplastic agent. It can be attached to a monoclonal antibody which directs it toward cancer cells. The NHS ester is able to react specifically and efficiently with amines (e.g. the side chain of lysine residues or aminosilane-coated surfaces) at neutral or slightly basic condition to form a covalent bond. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Bromide-Val-Cit-PAB-MMAE is a synthetic antibody-drug conjugate (ADC) coupled to a bromide group, which is a very good leaving group for nucleophilic substitution reactions. It contains a protease-sensitive Val-Cit dipeptide and an MMAE payload, which is a synthetic antineoplastic agent that can be attached to a monoclonal antibody (mAb) for targeting cancer cells. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Azide-Val-Cit-PAB-OH functions as a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). The Val-Cit will specifically be cleaved by Cathepsin B. The azide moiety participates in copper-catalyzed Click Chemistry reactions with alkyne, DBCO, and BCN. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Azide-PEG4-Val-Cit-PABC-Exatecan is an enzymatically cleavable linker-payload conjugate, and it can be used in the synthesis of antibody-drug conjugates (ADCs). The Val-Cit will specifically be cleaved by Cathepsin B. Exatecan is a structural analog of camptothecin and shows anticancer activity. The azide group can react with alkyne, BCN, and DBCO via Click Chemistry.

Sulfo TCO-Maleimide is a water-soluble reagent for attaching TCO moieties to cysteine-containing peptides or other thiol-containing molecules. The maleimide group selectively reacts with reduced thiols at pH 6.5-7.5, forming stable thioether bonds. The hydrophilic sulfonated spacer enhances water solubility, and the short spacer arm adds minimal mass to the modified molecules. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.