Click Chemistry

Iodoacetamide alkyne is a cysteine-reactive probe that covalently binds cysteine residues in proteins and peptides to an alkyne group. The alkyne can be used in click chemistry to attach fluorophores or biotin, allowing visualization by in-gel fluorescence or identification by mass spectrometry. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

MAL-PEG24-amido-PEG24-amido-PEG24-DSPE includes DSPE connected via hydrophilic PEG arms to maleimide, which will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol. The hydrophobic DSPE encapsulates hydrophobic drugs, while the hydrophilic PEG arms improve water solubility for effective drug delivery.

Azide-PEG4-Val-Cit-PAB-SN-38 serves as a cleavable ADC linker conjugated to SN-38, an anti-tumor drug and active metabolite of irinotecan. SN-38 inhibits DNA topoisomerase I, halting DNA synthesis and causing single-strand breaks. The Val-Cit linker is cleaved by lysosomal Cathepsin B, ensuring targeted intracellular release. The azide group participates in copper-catalyzed click chemistry with alkyne, DBCO, and BCN. The PEG spacer imparts water solubility to the molecule and helps optimize DMPK properties.

3,4-Dibromo-Mal-PEG8-Boc-Amine functions as a site-specific ADC linker with a dibromomaleimide group and boc-protected amine that can be hydrolyzed under acidic conditions to produce a free amine which is reactive to an activated succinimidyl (NHS) ester. The dibromomaleimide group allows for two points of substitution due to the two bromine atoms. Dibromo-Maleimide is sensitive to high temperature and light. The hydrophilic PEG8 spacer improves the aqueous solubility of the compound and aids in optimizing DMPK properties. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

DLG-PEG 2000 (18:2)

Mal-PEG8-Val-Ala-PAB is an ADC linker with a Val-Ala dipeptide that can be cleaved by Cathepsin B and Maleimide (Mal) group that is reactive toward thiol groups. The PEG8 chain enhances the water-solubility of the molecule and assists in fine-tuning DMPK properties.

(+)-JQ-1-PEG4-Amido-N-t-Boc possesses a Boc-protected amino (NH2) group, which is reactive with activated NHS esters or carboxylic acid in the presence of EDC or HATU, and (+)-JQ-1, which functions as a potent, specific, and reversible pan-BET (bromodomain and extra-terminal motif) family inhibitor. t-Boc-aminooxy can be deprotected under mild acidic conditions. (+)-JQ-1 can be a useful chemical probe to investigate the role of BET bromodomains in the transcriptional regulation of oncogenesis. The PEG4 spacer bolsters hydrophilicity.

1-(PEG-Amine)-2,3-(PEG4-Azide) is a branched PEG linker with a terminal amine that can be further derivatized for conjugation and two terminal azides that participate in click chemistry with linear alkynes, DBCO, and BCN.

Azide-PEG8-Val-Cit-PAB-MMAF serves as a linker-payload containing an azide click chemistry handle for click reactions with DBCO, BCN, and linear alkynes. MMAE is a synthetic antineoplastic agent which can be employed as a payload in the construction of ADCs (antibody-drug conjugates).The PEG chain enhances the water-solubility of the molecule.