Lipids & Polymers

BB1-NHS ester is amine reactive at pH 7-9 to form a stable, irreversible amide bond. It was used in a unique chemselective "unclickable' bioconjugation strategy to site specifically modify proteins. Ref: P. Andy, S. ERickson, J. Italia, A. Chatterjee, JACS, 2017, 139 (34), 11670-11673 Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

BB1-acid was used in a unique chemselective "unclickable' bioconjugation strategy to site specifically modify proteins. Ref: P. Andy, S. ERickson, J. Italia, A. Chatterjee, JACS, 2017, 139 (34), 11670-11673 Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Azide-PEG2-Tos is a small PEG linker featuring an azide and a tosylate. Tosylates are good leaving groups which are easily displaced by nucleophiles while azide is a click chemistry handle which is used to react with terminal alkynes or strained cyclooctynes.

TCO-PEG6-TCO is a homobifunctional PEG linker featuring a two trans-cyclooctenes. TCO is a click chemistry handle which readily reacts with tetrazine-containing compounds.

DC-Cholesterol HCl is a cholesterol derivative featuring an ionizable tertiary amine. Ionizable lipids are primarily used in lipid nanoparticle development, where the cationic properties of such lipids work to stabilize the LNP.

Lipid 5, also known as 7-[(2-Hydroxyethyl)[8-(nonyloxy)-8-oxooctyl]amino]heptyl 2-octyldecanoate, is a derivative of ALC-0315. It serves as a synthetic, ionizable lipid in conjunction with other lipids to form lipid nanoparticles (LNPs) for drug delivery. The pKa is 6.2. Reagent grade, for research use only.

1,1'-[2-(Hydroxymethyl)-1,3-propanediyl] dilinoleate is a lipid molecule featuring two linoleic acids and a primary alcohol. Compounds such as this may be used as intermediates in building lipids for use in lipid nanoparticles.

3-Hydroxy-2-(hydroxymethyl)propyl (9Z,12Z)-9,12-octadecadienoate is an unsaturated lipid linked by an ester to a central carbon and two hydroxyl groups which may be used for further derivitization.

Bis-PEG13-TFP ester is a homobifunctional PEG linker featuring two TFP esters, which easily react with nucleophiles such as primary amines and alcohols to form amides or esters respectively. TFP esters are more stable and less reactive than their NHS counterparts.