Lipids & Polymers

Boc-Aminooxy-PEG2-C2-amine is a polyethylene glycol (PEG)-based linker molecule designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs) [1].

(S, R, S)-AHPC-PEG4-NH2 hydrochloride is a chemically synthesized conjugate consisting of an E3 ligase ligand-linker, incorporating the VHL ligand based on (S, R, S)-AHPC, and a 4-unit PEG linker, which are specifically designed for use in PROTAC technology.

HO-PEG21-OH is a PEG-based linker for PROTACs, enabling the selective degradation of proteins by connecting two essential ligands and utilizing the ubiquitin-proteasome system within cells.

Mal-PEG2-alcohol, a PEG-based linker for PROTACs, joins two essential ligands crucial for forming PROTAC molecules, enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Mal-PEG3-NHS ester, a noncleavable ADC linker, possesses a Maleimide group. It serves as a crucial component in the synthesis of antibody-drug conjugates[1].

Mal-PEG6-NHS ester is a noncleavable ADC linker comprising a Maleimide functional group, a 6-unit Polyethylene Glycol (PEG) spacer, and an N-Hydroxysuccinimide (NHS) ester moiety.

Mal-PEG6-PFP ester is a PEG-based linker for PROTACs that joins two essential ligands, facilitating selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Methyltetrazine-PEG5-NHS ester, a PEG-linked PROTAC linker, enables the synthesis of PROTACs[1].

N-(Amino-PEG5)-N-bis(PEG4-acid) is a PEG-based PROTAC linker used for synthesizing PROTACs, consisting of an amino group and two terminal carboxylic acids[1].