PEG

tert-butyl 2-(2,5-dioxo-2H-pyrrol-1(5H)-yl)ethylcarbamate contains a maleimide group and a Boc-protected amine group. The protected amine can be deprotected under acidic conditions. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Mal-Amido-PEG4-t-butyl ester is a PEG linker containing a maleimide group and a t-butyl ester group. The hydrophilic PEG spacer increases solubility in aqueous media. The t-butyl protected carboxyl group can be deprotected under acidic conditions. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Bis-Mal-PEG3 is a PEG linker containing a two maleimide groups. The maleimide groups will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol. The hydrophilic PEG spacer increases solubility in aqueous media. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Mal-amido-PEG4-acid is a PEG linker containing a maleimide group and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Mal-PEG4-PFP is a PEG linker with maleimide and PFP moieties. Maleimides are thiol reactive between pH 6.5 and 7.5, forming thiolester bonds. The PFP is amine reactive and forms stable amide bonds. PFP was also found to be less susceptible toward hydrolysis than other amine reactive groups. The hydrophilic PEG linker increases the water solubility of a compound in aqueous environments. Increasing the number of units in the PEG chain ehnahces their solubility properties. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Mal-PEG6-PFP is a PEG linker with maleimide and PFP moieties. Maleimides are thiol reactive between pH 6.5 and 7.5, forming thiolester bonds. The PFP is amine reactive and forms stable amide bonds. PFP was also found to be less susceptible toward hydrolysis than other amine reactive groups. The hydrophilic PEG linker increases the water solubility of a compound in aqueous environments. Increasing the number of units in the PEG chain ehnahces their solubility properties. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Tos-PEG6-t-Butyl ester is a PEG linker containing a t-butyl ester and a tosyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The t-butyl protected carboxyl group can be deprotected under acidic conditions. The tosyl group is a very good leaving group for nucleophilic substitution reactions. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Bromo-PEG5-t-butyl ester is a PEG linker containing a bromide group and a t-butyl protected carboxyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The bromide (Br) is a very good leaving group for nucleophilic substitution reactions. The t-butyl protected carboxyl group can be deprotected under acidic conditions. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Azide-PEG5-t-butyl ester is a click reagent containing an azide with azide (N3) group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.