PEG

m-PEG-CH2CO2H, MW 30,000 is a monofunctional polydisperse PEG which can react with amino molecule in the presence of activator (HATU or EDC) via amide bond formation. Reagent grade, for research purpose.

Diazo-PEG3-TCO consists of a diazo group for efficient release of captured molecules and three PEG units for enhanced water-solubility. TCO is a click chemistry handle which readily reacts with tetrazine groups on a target molecule.

Sulfo DBCO-PEG4-TFP ester is a short PEG linker featuring a DBCO group, a sulfate, and a TFP ester. DBCO is a click chemistry handle which efficiently reacts with azide groups on target molecules, while the TFP is a good leaving group which is readily displaced by nucleophiles such as amines. Finally, the sulfate group is able to increase the solubility of this linker.

Methyltetrazine-PEG3-amine is a short PEG linker featuring a methyltetrazine and a primary amine. The methyltetrazine can be reacted with TCO for a high-yield click reaction while the amine easily reacts with carboxylic acids in the presence of reagents such as HATU or EDC to form amide bonds. Amines are also useful in reductive amination, and heterocyclic chemistry.

m-PEG-bromide, MW 2,000 is a monofunctional PEG polymer. The bromide moiety is a good leaving group for nucleophilic substitution reactions. Reagent grade, for research purpose.

endo-BCN-OH is a click chemistry handle which readily reacts with azides. The primary alcohol allows it to be ligated to other linkers.

Diazo-PEG3-methyltetrazine is a TCO reactive reagent with a PEG3 linker for improved water-solubilitiy and a diazo group for efficient release of captured molecules.

4-(N-methyl-N-phenylamino)butanoic NHS ester is a short linker featuring a methylaniline and an NHS ester. The NHS is a good leaving group which is easily displaced by nucleophiles while methylaniline is a highly electron-dense heterocycle with a variety of chemical uses.

m-PEG-bromide, MW 5,000 is a large PEG molecule containing a methoxy and a bromide. The methoxy group caps one end of the molecule to allow the PEGylation of a target molecule to proceed on only one end of this molecule at the terminal bromide. PEG linkers with high molecular weights such as this one are frequently employed in developing PEG-lipid conjugates such as the ones used to create lipid nanoparticles for drug delivery.