PEG

Thalidomide-O-amido-PEG-C2-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate, incorporating a Thalidomide-based cereblon ligand and a linker. This compound is used in the synthesis of PROTACs.

PEG400 (Polyethylene glycol 400) is a polymer formed from repeating units of ethylene glycol that is water soluble, low immunogenicity, and biocompatible. PEG400 is a neutral polymer with a molecular weight of 400.

Pomalidomide-PEG2-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based CRBN ligand and linker used in PROTAC technology.

DMG-PEG2000

DMG-PEG2000

Maleimide PEG NHS, MP 10,000

Diethyl 6-bromohexylphosphonate is a short linker featuring a bromide and a diethyl phosphonate. The bromide is a good leaving group which can be easily displaced by nucleophiles like alcohols, amines or thiols, while the diethyl phosphonate may be hydrolyzed to allow for esterification.

DOTA(OtBu)3 contains a DOTA moiety with t-butyl groups which can be used as a chelating agent for cations and is commonly used for imaging diagnostics. The t-butyl protected carboxyl group can be deprotected under acidic conditions. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Lenalidomide-OH is a E3 ligase activator used in the development of PROTACs.