PEG

PCL(2k)-mPEG(1k) is a micelle-forming polymer with hydrophobic polycaprolactone tethered to a hydrophilic PEG. The PCL segment can be used to encapsulate hydrophobic drugs while the PEG can form a tight shell around the core to minimize drug degradation. The polymer is biodegradable via hydrolytic attack on the PCL ester bonds. Reagent grade, for research purpose.

PCL(2k)-mPEG(2k) possesses two distinct block of polymers, i.e. hydrophobic polycaprolactone (PCL) and hydrophilic PEG blocks. Upon dispersion in water, the polymer self-assembles with the PCL being shielded from water by the PEG. The PCL core can be used to encapsulate hydrophobic drugs. On the other hand, the PEG shell not only provides protection against degradation but also enables a stealth behavior which is a prerequisite for successful in vivo translation of nanomedicine to achieve long blood circulation and targeted delivery. Reagent grade, for research purpose.

PCL(5k)-mPEG(5k) has a hydrophobic polycaprolactone (PCL) block chemically tethered to a hydrophilic PEG block. Upon dispersion in water, the polymer self assembles to form micelles with PCL core and PEG shell. In drug delivery application, the core regions serves as reservoirs for hydrophobic drugs while the shell regions provide protection against protein adsorption which can lead to degradation (via enzymatic or hydrolysis). Reagent grade, for research purpose.

PCL(10k)-mPEG(5k) is made of two distinct polymers with different hydrophilicity. One of the block is hydrophilic PEG and the other one is hydrophobic polycaprolactone (PCL). The different hydrophilicity allows the polymer to self-assemble in water with arrangement of PEG facing the water surface and PCL being shieled from the water. The core regions can be used to encapsulate hydrophobic drugs for sustained drug delivery. Reagent grade, for research purpose.

mPEG(2k)-PCL(1k)-COOH can react with protein/peptide or other amino molecule in the presence of activator, such as HATU/EDC. The copolymer is amphiphilic which can self-assemble in aqueous solution to form polymeric micelles. The core regions of the micelles are made of polycaprolactone (PCL) and can be used as hydrophobic drugs reservoir for targeted drug delivery. Reagent grade, for research purpose.

Acid-PEG25-Amide-Tri(3-methoxypropanamide-PEG10-Azide) Methane is a branched PEG linker with a terminal carboxylic acid group and three terminal azide groups. The azide groups enables PEGylation via Click Chemistry.

PCL(1k)-PEG(2k)-COOH is a monofunctional amphiphilic block copolymer. The biodegradable polymer can form micelles in water and can be used for drug encapsulation in drug delivery. The carboxyl (COOH) is reactive to amine in the presence of activating agent, such as HATU/EDC to form a stable amide bond. The polyester, polycaprolactone (PCL), is biodegradable via hydrolytic attack on the ester bonds. Reagent grade, for research purpose.

PCL(1k)-PEG(1k)-FITC is an amphipathic block copolymer with green fluorescent probe for staining cells, tissues, biomarkers or nanoparticles. FITC has peak absorption or excitation at 494 nm and maximum emission at 521 nm. The molecule can form micelles spontaneously in water. It can be used to prepare nanocarrier for delivering therapeutic agents. Reagent grade, for research purpose.

PCL(3k)-PEG(2k)-NH2 is a self-assembling block copolymer with terminal amine which is reactive with NHS-ester to form a stable amide linkage. The polymer is commonly used to encapsulate drugs for controlled release drug delivery system. Reagent grade, for research purpose.