PEG

PLGA(20k)-PEG(5k)-MAL is a block copolymer containing poly(lactide-co-glycolide) (PLGA) (hydrophobic) and PEG (hydrophilic). Upon dispersion in water, the polymer self-assembles to form micelles with PLGA core and PEG shell. The core can be used as reservoir for hydrophobic drugs while the shell can provide protection from degradation (enzymatic/hydrolysis). The terminal maleimide is reactive with thiol (SH) at physiological pH 6.5-7.5 via thioether bond formation. Reagent grade, for research purpose.

PLGA(5k)-PEG(1k)-N3 is click chemistry polymer. The azide can undergo azide-alkyne cycloaddition with cyclooctyne (Cu free) or terminal alkyne (with Cu catalyst) to form a stable triazole bond. The amphiphilic polymer can self assemble in water to form micelles with core and shell contains poly(lactide-co-glycolide) (PLGA) and PEG, respectively. It can be used to encapsulate hydrophobic drugs. Reagent grade, for research purpose.

PLGA(10k)-PEG(2k)-N3 is a linear amphiphilic polymer with PEG as a hydrophilic block and poly(lactide-co-glycolide) (PLGA) as a hydrophobic one. The polymer can form micelles when dispersed in water with the PEG facing the water (shell) and PLGA being shielded from the water (core). The terminal alkyne can react with various alkyne moieties, such as DBCO, BCN, or terminal alkyne to form a stable triazole bond. The PLGA core can be used to encapsulate hydrophobic drugs in nanomedicine/targeted delivery application. Reagent grade, for research purpose.

PLGA(10k)-PEG(5k)-N3 is a micelles-forming block copolymer with poly(lactide-co-glycolide) (PLGA) as a hydrophobic segment and PEG as a hydrophilic block. The terminal azide of the polymer is reactive with cyclooctyne, such as DBCO/BCN, to form a stable triazole bond via SPAAC. Additionally, the polymer can also react with a terminal alkyne in the presence of copper catalyst via CuAAC. This class of polymer can be used to encapsulate drugs for nanomedicine and targeted drug delivery. Reagent grade, for research purpose.

PLGA(5k)-PEG(5k)-NH2 is an amino terminated amphiphile polymer. The terminal amine can react with NHS ester at pH 7-9 to form a stable amide linkage. Upon dispersion in water, the polymer self-assembles to form micelles with poly(lactide-co-glycolide) (PLGA) core and PEG shell. The core can be used as hydrophobic drugs reservoir while the shell can protect against enzymatic/hydrolysis degradation. The polymer is biodegradable and can be used for sustained release drug delivery. Reagent grade, for research purpose.

PLGA(10k)-PEG(1k)-NH2 is an biocompatbile amphiphilic copolymer which can self-assemble in water to form micelles/nanoparticles. The polymer can be used to prepare nanomicellar/nanoparticles for drug delivery application. It has a terminal amine which is reactive with NHS ester readily or with a carboxyl in the presence of activator, such as HATU or EDC. Reagent grade, for research purpose.

PLGA(20k)-PEG(5k)-NH2 is a monofunctional amphiphilic block copolymer with terminal amine. The polymer can react with a N-Hydroxysuccinimide (NHS) ester in physiological condition via amide bond formation. The self-assembling polymer can be used to prepare drug loaded nanoparticles where the drugs are encapsulated in the core of the micelles which then be delivered to a specific target. Reagent grade, for research purpose.

PLGA(1k)-PEG(1k)-NHS is an amphiphilic polymer with a terminal NHS ester which is reactive with primary amine via amide bond formation. The block copolymer contains a hydrophobic poly(lactide-co-glycolide) (PLGA) block chemically attached to a hydrophilic PEG block. Upon dispersion in water, the polymer self assembles to form micelles which can encapsulate drugs for drug delivery. Reagent grade, for research purpose.

PLGA(2k)-PEG(1k)-NHS is a water insoluble block copolymer with succinimidyl terminal group. It is reactive with primary amine via formation of a stable amide bond. The polymer forms micelles in water and can be used to encapsulate hydrophobic drugs. Reagent grade, for research purpose.