PEG

PLGA(4k)-PEG(1k)-NHS is reactive with amine nucleophile to form a stable amide bond. The block copolymer is amphiphilic which can self-assemble in water to form core-shell nanoparticles/micelles. The core regions contains poly(lactide-co-glycolide) (PLGA) which can be used to entrap hydrophobic drugs. Reagent grade, for research purpose.

PLGA(10k)-PEG(1k)-NHS is an active NHS ester functionalized polymer. The succinimidyl ester group can react with an amine to form a stable amide bond. It is biodegradable block copolymer with poly(lactide-co-glycolide) (PLGA) hydrophobic block tethered to a PEG hydrophilic block. The polymer can self-assemble in water to form micelles which can be used to formulate controlled realease drug delivery system. Reagent grade, for research purpose.

PLGA(10k)-PEG(3k)-NHS is an active ester block copolymer for bioconjugation with primary amines at pH 7-9 to form a stable amide linkage. The self-assembling polymer can be used to prepare nanocarrier used in nanomedicine. The poly(lactide-co-glycolide) (PLGA) block is biodegradable via hydrolysis of the ester bonds. Reagent grade, for research purpose.

PLGA(10k)-PEG(5k)-NHS is a linear amphiphilic bioconjugation polymer which can react with a primary amine molecule at pH between 7-9 to form a stable amide linkage. Upon dispersion in water, the polymer self-assembles with the poly(lactide-co-glycolide) (PLGA) being shielded from water by the PEG. The PLGA core can be used to encapsulate hydrophobic drugs. On the other hand, the PEG shell not only provides protection against degradation but also enables a stealth behavior which is a prerequisite for successful in vivo translation of nanomedicine to achieve long blood circulation and targeted delivery. Reagent grade, for research purpose.

Acid-PEG25-Amide-Tri(3-methoxypropanamide-PEG23-Azide) Methane is a branched PEG compound with a terminal carboxylic acid and three terminal azide groups. The hydrophilic PEG spacer increases solubility in aqueous media. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. HATU) to form a stable amide bond.

PLGA(1k)-PEG(1k)-Thiol is a maleimide-reactive block copolymer which forms a stable thioether linkage. The polymer can form nanoparticles/micelles in water and be used to formulate drug nanocarrier. Reagent grade, for research purpose.

PLGA(3k)-PEG(5k)-Thiol is a biodegradable block copolymer with hydrophobic poly(lactide-co-glycolide) (PLGA) and hydrophilic PEG. The polymer can be used for formulation of nanomicellar for sustained drug delivery. The terminal hydroxyl (OH) can be used for further derivatization while the terminal thiol can react with maleimide to form a stable thioether bond. Reagent grade, for research purpose.

PLGA(5k)-PEG(3k)-PLGA(5k) allows self-assembly to form micelles with the poly(lactide-co-glycolide) (PLGA) as core and PEG as shell. The core regions can serve as hydrophobic drugs reservoir while the shell can provide protection against degradation. Furthermore, the PEG shell also allows the "stealth behavior" which is a prerequisite for successful in vivo translation of nanomedicine to achieve long blood circulation and targeted delivery. The ester bonds of the polymer can be degraded via hydrolytic attack. Reagent grade, for research purpose.

t-butyl ester-PEG25-Amide-Tri(3-methoxypropanamide-PEG23-Azide) Methane is a branched PEG linker with a terminal t-butyl group and three terminal azide groups. The t-butyl group can be deprotected under acidic conditions. The azide groups enables PEGylation via Click Chemistry.