PEG

t-Boc-Aminooxy-PEG10-acid is a PEG linker containing a Boc-protected aminooxy group and a terminal carboxylic acid. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. HATU) to form an amide bond. The hydrophilic PEG spacer increases solubility in aqueous media. The Boc-protected amine can be deprotected under mild acidic conditions.

PEG8-bis(C3-amine) is a conjugation linker containing two amine groups. The hydrophilic PEG spacer increases solubility in aqueous media. The amino groups are reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde), etc.

MZ1 is a PROTAC compound that is selective for proteasomal degradation of bromodomain-containing protein 4 (BRD4) in HeLa cells . MZ1 contains JQ-1, which binds bromo- and extra-terminal (BET) proteins, linked to a ligand for the E3 ubiquitin ligase VHL. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

ARV-825 is a PROTAC molecule composed of a BRD4 binding moiety joined to an E3 ligase cereblon binding moiety. ARV-825 recruits BRD4 to E3 ubiquitin ligase cereblon, resulting in the degradation of BRD4. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Pomalidomide-PEG4-Ph-NH2 comprises the Pomalidomide based cereblon ligand and 4-unit PEG linker used in PROTAC technology. Pomalidomide-PEG4-Ph-NH2 is used in PROTAC technology as a E3 ligase ligand-linker conjugate that incorporatess PEG technology that can be linked to a wide range of "warheads" that bind to proteins of interest. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Thalidomide-O-acetamido-C4-amine HCl salt comprises a Thalidomide based cereblon ligand and a ligand-linker conjugate. This E3 ligase ligand-linker conjugate is used in PROTAC technology. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Pomalidomide 4'-PEG3-azide is an E3 ligase ligand-linker that incorporatess the Pomalidomide-based cereblon ligand and a linker. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

P131 is a PROTAC molecule comprised of Pomalidomide-based cereblon ligand and IBT6A, linked by a PEG 3 chain. P131 was initial developed by Sun (2018) that can degrade both wild-type and C481S mutant BTK with nanomolar potencies. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

(S, R, S)-AHPC-PEG3-amine hydrochloride salt comprises VHL Ligand coupled to an amine via a PEG3 linker. The VHL Ligand 1 is a synthetic compound used in PROTAC research based on E3 ligase ligand. NH2 group is reactive with carboxylic acids in the presence of coupling reagent such as EDC, or directly with NHS esters, to form a stable amide bond. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.