PEG

N-(t-butyl ester-PEG3)-N-bis(PEG3-azide) is a branched conjugation reagent with a terminal t-butyl group and a terminal pair of azide groups. The azide groups are very reactive with alkynes such as DBCO, BCN and propargyl via Click Chemistry. The t-butyl group can be deprotected under acidic conditions. The hydrophilic PEG spacer increases the hydrophilic properties of the compound.

Bis-PEG12-NHS ester is composed of 12 PEG units with two amino groups. Amino groups are reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde), etc.

Methyltetrazine-PEG5-amine HCl salt is an aqueous soluble PEGylation reagent containing a free amine and a methyltetrazine group. The methyl group improves the stability and the hydrophilic PEG spacer increases water-solubility. Methyltetrazine enables fast click reaction with TCO (trans-cycloctene).

N-(t-butyl ester-PEG3)-N-bis(PEG3-amine) is a branched conjugation reagent with a terminal t-butyl group and a terminal pair of amine groups. The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde), etc. The t-butyl group can be deprotected under acidic conditions. The hydrophilic PEG spacer increases the hydrophilic properties of the compound.

N-(t-butyl ester-PEG3)-N-bis(PEG3-Mal) is a branched conjugation reagent with a terminal t-butyl group and a terminal pair of maleimide groups. The maleimide group will react with a thiol group to form a covalent bond. The t-butyl group can be deprotected under acidic conditions. The hydrophilic PEG spacer increases the hydrophilic properties of the compound.

Methyltetrazine-PEG5-NH-Boc is a click chemistry crosslinker containing methyltetrazine and a Boc protecting group. Methyltetrazine enables fast click reaction with TCO (trans-cycloctene). The hydrophilic PEG spacer arm improves water solubility and is transferrable to the labeled molecule, reducing aggregation of labeled proteins stored in solution. The Boc protecting group can be removed under acidic conditions.

(1R,8S,9s)-Bicyclo[6.1.0]non-4-yn-9-ylmethyl Succinimidyl Carbonate is a Succinimidyl ester/NHS-functionalized cyclooctyne derivative for addition of the cyclooctyne moiety into amine-containing compounds or biomolecules. The BCN group can react with azide-tagged biomolecules under copper free conditions.

3-{5,7-dioxo-5H,6H,7H-pyrrolo[3,4-b]pyridin-6-yl}piperidine-2,6-dione is a thalidomide analog that can be useful in PROTAC research.

5-Amino-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione is a thalidomide analog that can be useful in PROTAC research.