PEG

Thalidomide-5-(PEG2-acid) is a PROTAC building block that contains an E3 ligase ligand substituted with carboxylic acid. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. HATU) to form a stable amide bond. The PEG spacer improves water solubility.

Thalidomide-5-(PEG4-acid) is a PROTAC building block that contains an E3 ligase ligand substituted with carboxylic acid. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. HATU) to form a stable amide bond. The PEG spacer improves water solubility.

SPDP-PEG3-acid is a heterobifunctional PEG polymer which is reactive with an amine in the presence of activating agent (HATU/EDC) and with a thiol to form a disulfide bond.

Tri(propargyl-PEG10-NHCO-ethyloxyethyl)amine is a click chemistry branched linker with three terminal azide groups. The hydrophilic PEG spacer increases solubility in aqueous media. The azide group can react with alkyne, BCN, DBCO via Click Chemistry.

DBCO-S-S-acid is a cleavable reagent for introduction of a carboxylic acid moiety to azide-containing biomolecules using copper-free Click Chemistry. PEG spacer arm provides better solubility to the labeled molecules in aqueous media. The disulfide bond in this linker can be cleaved using reducing agents such as DTT, BME and TCEP.

F-PEG2-SO2-CH2COOH is a PEG linker containing a fluorine and sulfonic acid moieties. The sulfone group can participate in esterification, halogenation and replacement reactions. The hydrophilic PEG linkers increase the water solubility of the compound in aqueous media.

Iodoacetamido-PEG6-azide is an aqueous soluble PEG linker containing an azide and a terminal Iodoacetamido group. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The Iodoacetamido moiety is commonly used to bind covalently with the thiol group of cysteine so the protein cannot form disulfide bonds.

Iodoacetamido-PEG6-acid is a aqueous soluble PEG linker containing a terminal carboxylic acid and Iodoacetamido group. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. HATU) to form a stable amide bond. The Iodoacetamido moiety is commonly used to bind covalently with the thiol group of cysteine so the protein cannot form disulfide bonds.

F-PEG2-CH2COOH is a PEG linker containing a fluorine and carboxylic acid moieties. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. HATU) to form a stable amide bond. The hydrophilic PEG linkers increase the water solubility of the compound in aqueous media.