PEG

[2-(Fmoc-amino)acetamido]-acid is a cleavable ADC linker with an Fmoc group and a terminal carboxylic acid group. The Fmoc group can be deprotected under basic conditions to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. HATU) to form a stable amide bond. Reagent grade, for research use only.

Inosine is a purine ribonucleoside that is frequently encountered in tRNA and signaling pathways more so than in canonical DNA/mRNA/protein biosynthesis.

DBCO-PEG4-amine is a PEG linker which contains DBCO and amine moieties. The DBCO group is commonly used in copper-free Click Chemistry reactions. The amine group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde), etc. The hydrophilic PEG spacer increases the water solubility of the compound. Reagent grade, for research purpose.

NH-bis(PEG8-azide) is a bifunctional linker with two azides joined together by a secondary amine. The azides are useful for click chemistry with terminal alkynes or strained cyclooctynes while the amine can be used in reactions with carboxylic acids, ketones and aldehydes.

N-Mal-N-bis(PEG8-NHS ester) is a trifunctional linker with two NHS esters and a maleimide function. The NHS esters are activated towards attack from a nucleophile such as amines or alcohols while the maleimide serves as a covalent ligand to strongly bind thiols such as those found in the amino acid, cysteine.

Azido-PEG12-amine is a water soluble PEG compound. The azide group enables Click Chemistry. The amine group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde), etc. The hydrophilic PEG arm increases solubility in aqueous media. Reagent grade, for research use only.

TCO-PEG4-maleimide is a click chemistry building block containing a TCO moiety and a maleimide group. The maleimide group will react with a thiol group to form a covalent bond. TCO moiety is very reactive with tetrazine (3rd generation click chemistry). Reagent grade, for research purpose.

Methoxycarbonyl-PEG5-t-butyl ester is a short PEG linker featuring a methyl ester and a tert-butyl ester. The methyl ester can be selectively deprotected with mild base to allow for reactivity as a carboxylic acid to form esters or amides.