PEG

Azido-PEG12-azide is an aqueous soluble, monodisperse PEG linker containing two azide groups. The azide group can react with alkyne, BCN, or DBCO via Click Chemistry to yield a stable triazole linkage. Reagent grade, for research use only.

7-bromoheptyl dodecanoate has a terminal bromine and a non-polar tail. 7-bromoheptyl dodecanoate can be used for the building or modification of lipid nanoparticles. Reagent grade, for research use only.

DBCO-PEG-amine TFA salt, MW 2,000 is a polyPEG linker which contains DBCO and amine moieties. The DBCO group is commonly used in copper-free Click Chemistry reactions. The amine group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde), etc. The hydrophilic PEG spacer increases the water solubility of the compound. Reagent grade, for research use only.

DBCO-C5-acid is an analog of DBCO-Acid with an extended 5-carbon atom spacer arm. The extended 6-carbon atom spacer arm improves its derivatization efficiency and the stability of the yielded conjugates. This spacer arm also improves solubility in organic solvents such as dichloromethane, chloroform, THF, and ethyl acetate. DBCO is commonly used for copper-free Click Chemistry reactions. Reagent grade, for research use only.

t-Boc-N-amido-PEG8-NHS ester is a PEG linker containing an NHS ester and a Boc-protected amino group. The hydrophilic PEG spacer increases the water solubility of a compound in aqueous media. The Boc group can be deprotected under mild acidic conditions to form a free amine. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. Reagent grade, for research use only.

Bromo-PEG11-azide is a PEG linker containing a bromine and an azide group. The hydrophilic PEG spacer increases solubility in aqueous media. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The bromine (Br) is a very good leaving group for nucleophilic substitution reactions. Reagent grade, for research use only.

DBCO-PEG4-Butyraldehyde is a click chemistry PEG reagent containing a terminal butylraldehyde group. Butyraldehyde reacts with hydrazide to form a stable hydrazone linkage or with alkoxyamines to form a stable oxime bond. The hydrophilic PEG spacer arm improves water solubility and provides a long and flexible connection that minimizes steric hindrance involved with ligation. DBCO is commonly used for copper-free Click Chemistry reactions. Reagent grade, for research use only.

(S, R, S)-AHPC-PEG8-Amine, HCl salt is a synthetic PROTAC linker molecule that incorporatess an E3 ligase ligand with a PEG linker to empower PROTAC drug research & discovery. The amino group (NH2) is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The hydrophilic PEG spacer increases the solubility of a compound in aqueous media. Reagent grade, for research use only.

t-Boc-N-amido-Tri-(propargyl-PEG10-ethoxymethyl)-methane is reactive with azide-bearing compounds or biomolecules via copper catalyzed azide-alkyne Click Chemistry to yield a stable triazole linkage. The Boc group can be deprotected under mild acidic conditions to form the free amine. Reagent grade, for research use only.