PEG

Amine-PEG4-Amide-Tri(3-methoxypropanamide-PEG10-Propargyl) Methane HCl salt is a crosslinker consisting of an amino group with three propargyl groups. The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde), etc. The propargyl groups can form triazole linkage with azide-bearing compounds or biomolecules via copper catalyzed Click Chemistry. Reagent grade, for research use only.

t-Boc-N-amido-PEG4-Amide-Tri-(propargyl-PEG10-ethoxymethyl)-methane is a branched crosslinker molecule with three terminal propargyl groups and a t-Boc protected amide group. The propargyl groups can react with azide-bearing compounds or biomolecules via copper catalyzed azide-alkyne Click Chemistry to yield a stable triazole linkage. The protected amine can be deprotected under acidic conditions. Reagent grade, for research use only.

D-acid-PEG4-Thalidomide-5-(PEG4-acid) is a PROTAC linker that can react with two amine-containing moieties in the presence of activator EDC or HATU. Reagent grade, for research use only.

t-Boc-N-amido-PEG12-azide consist of an azide group, Boc-protected amino group, and 12 PEG units. The azide group can react with alkyne, BCN, DBCO via Click Chemistry. The hydrophilic PEG spacer increases solubility in aqueous media. Reagent grade, for research use only.

DSPE-hydrazone-mPEG2K is a phospholipid polyPEG with a hydrazone group which can self-assemble to form lipid bilayer in aqueous solution. The polymer can be used to prepare liposomes as a drug delivery vehicle. Hydrazone linkages are useful for coupling drugs to targeted antibodies where the linkage is stable at neutral pH, but is rapidly destroyed in the acidic environment of lysosomes of the cell. Reagent grade, for research use only.

DBCO-PEG2-amine is a PEG linker which contains DBCO and amine moieties. The DBCO group is commonly used in copper-free Click Chemistry reactions. The amine group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde), etc. The hydrophilic PEG spacer increases the water solubility of the compound. Reagent grade, for research purpose.

4-Arm PEG5-DBCO is a 4-arm branched PEG linker with four DBCO moieties. The DBCO group is commonly used in copper-free Click Chemistry reactions. The hydrophilic PEG spacer increases the water solubility of the compound. Reagent grade, for research purpose.

Carboxy-Amido-PEG4-t-Boc-N-amido is a PEG linker containing a terminal carboxylic acid and Boc-protected amino group. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. HATU) to form a stable amide bond. The Boc group can be deprotected under mild acidic conditions to form the free amine. The hydrophilic PEG spacer increases solubility in aqueous media. Reagent grade, for research purpose.

Amine-PEG-amine HCl salt, MW 2,000 is an HCl salt of a homobifuctional diamines polyPEG. This compound is useful for modification of biological molecules by covalent conjugation as a strategy to overcome disadvantages associated with some biopharmaceuticals. Reagent grade, for research purpose.