PEG

mPEG-DPPE, 2,000 MW is composed of two fatty acids, a glycerol unit, a phosphate group and a polyPEG head. The phosphate group and polar head region of the molecule is hydrophillic, while the fatty acid tail is hydrophobic. mPEG-DPPE, 2,000 MW can be used for lipid nanoparticle (LNP) preparation for siRNA (small interfering RNA) delivery research. Reagent grade, for research purpose.

Azido-PEG8-Amido-Val-Cit-PAB is a cleavable ADC linker. The Val-Cit will specifically be cleaved by Cathepsin B. As this enzyme is only present in the lysosome, the ADC payload will be released only in the cell. Azido will react with DBCO, BCN or other alkyne groups through click chemistry. PEG spacer increases aqueous solubility. Reagent grade, for research purpose.

DBCO-PEG-NHS ester, 3,400 MW is a click chemistry polyPEG reagent containing NHS ester that is able to react specifically and efficiently with primary amines (e.g. the side chain of lysine residues or aminosilane-coated surfaces) at neutral or slightly basic condition to form a covalent bond. The hydrophilic PEG spacer arm improves water solubility and provides a long and flexible connection that minimizes steric hindrance involved with ligation. DBCO is commonly used for copper-free Click Chemistry reactions. Reagent grade, for research purpose.

DBCO-PEG-amine TFA salt, MW 5,000 is a polyPEG linker which contains DBCO and amine moieties. The DBCO group is commonly used in copper-free Click Chemistry reactions. The amine group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde), etc. The hydrophilic PEG spacer increases the water solubility of the compound. Reagent grade, for research use only.

nonyl 10-bromodecanoate is an intermidate for synthesis of lipid molecules. Reagent grade, for research purpose.

DBCO-PEG-NHS ester, MW 5,000 is a click chemistry polyPEG reagent containing NHS ester that is able to react specifically and efficiently with primary amines (e.g. the side chain of lysine residues or aminosilane-coated surfaces) at neutral or slightly basic condition to form a covalent bond. The hydrophilic PEG spacer arm improves water solubility and provides a long and flexible connection that minimizes steric hindrance involved with ligation. DBCO is commonly used for copper-free Click Chemistry reactions. Reagent grade, for research purpose.

4-Arm PEG5-Amine is a multiarm PEG linker containing four terminal amines which can be reacted with NHS ester in an aqueous solution at pH 7 to 9. Reagent grade, for research purpose.

1,1'-[2-[( 6-bromohexanoate)methyl]-1,3-propanediyl] dipentadecan-7-yl adipate has a terminal bromine and two 4,4-bis(octyloxy)butanoic acid tails. This compound can be useful for the building or modification of lipid nanoparticles. The bromine (Br) is a very good leaving group for nucleophilic substitution reactions. Reagent grade, for research purpose.

DBCO-PEG-NHS ester, 2,000 MW is a click chemistry polyPEG reagent containing NHS ester that is able to react specifically and efficiently with primary amines (e.g. the side chain of lysine residues or aminosilane-coated surfaces) at neutral or slightly basic condition to form a covalent bond. The hydrophilic PEG spacer arm improves water solubility and provides a long and flexible connection that minimizes steric hindrance involved with ligation. DBCO is commonly used for copper-free Click Chemistry reactions. Reagent grade, for research purpose.