PEG

PEG13-bis(Amino-Tri-(Propargyl-PEG2-ethoxymethyl)-methane) is large molecule with two sets of three terminal alkynes joined together by a large PEG linker. The alkynes are most frequently used in copper click chemistry with azides. The PEG linkers as well as numerous amide bonds provide high aqueous solubility to this compound, which may alter ADME of this compound.

(S, R, S)-AHPC-PEG4-N-Boc is a PROTAC linker featuring an AHPC group, a hydrophilic PEG linker, and a Boc-protected amine. (S, R, S)-AHPC is a ligand that activates E3 ligase, while the Boc protecting group can be removed with strong acid to reveal a primary amine which can participate in a wide variety of reactions.

mPEG-DMG, MW 5,000 is a large PEG lipid containing a DMG group and a methoxy cap. The methoxy cap is inert while the DMG group is a popular ligand for developing PEG-lipids and lipid nanoparticles more broadly. Varying the size of a PEG linker greatly impacts its molecular dynamics, thereby affecting DMPK and ADME properties of a given API.

2-(4-(2-aminoethyl)piperazin-1-yl)ethanamine is a piperazine with two N-ethanamine groups. This type of molecule may be used to build drug molecules or design novel ionizable aminolipid head groups for lipid nanoparticles.

DOTA-PEG10-azide is a chelating reagent featuring a DOTA group and an azide with PEG10 spacer. Azides are reactive with alkynes through click chemistry while DOTA chelates di- and trivalent cations for applications such as imaging diagnostics.

(S, R, S)-AHPC-PEG4-amine is a PROTAC linker featuring an AHPC group, a hydrophilic PEG linker, and an amine. (S, R, S)-AHPC is a ligand that activates E3 ligase, while the primary amine which can participate in a wide variety of reactions.

Azido-PEG8-Val-Cit-PAB-OH is a cleavable linker intermediate which contains an azide, a hydrophilic PEG spacer, a Val-Cit dipeptide, and a PAB group. The azide is free to perform click chemistry with terminal alkynes or strained cyclooctynes such as DBCO or BCN. The Val-Cit dipeptide is cleaved by cellular proteases within the cell to allow for efficient payload delivery via an elimination mechanism within the PAB structure.

t-Boc-N-amido-PEG-Succinimidyl Carbonate, MW 2,000 is a PEG linker containing a Boc-protected primary amine and a succinimidyl carbonate. The carbonate is a good leaving group, being easily substituted by nucleophiles such as amines and alcohols. The Boc group can be deprotected by acidic conditions, which frees the amine to react with functional groups such as carboxylic acids, aldehydes and ketones.

DSPE-PEG-Fluor 594, MW 2,000 is a PEG-lipid conjugate featuring a DSPE phospholipid and a Fluor 594 dye. DSPE is a phospholipid that is well-known to spontaneously form micelles in aqueous media, while Fluor 594 is a red, water-soluble dye with absorption and emission maxima at 590 and 617 nm respectively.