PEG

MZP-54 is a PROTAC connected by ligands for von Hippel-Lindau and BRD3/4, with a Kd of 4 nM for Brd4BD2.

BSJ-03-123 is a PROTAC connected by ligands for Cereblon and CDK as a potent and novel CDK6-selective small-molecule degrader.

PROTAC ERR alpha ligand 1 is an estrogen-related receptor alpha (ERR alpha) antagonist with IC50s of 0.04 and 2.8 μM for ERR alpha and ERR gamma, respectively.

PROTAC Sirt2 Degrader-1 is a SirReal-based PROTAC, acts as a Sirt2 degrader, composed of a highly potent and isotype-selective Sirt2 inhibitor, a linker, and a bona fide Cereblon ligand for E3 ubiquitin ligase. PROTAC Sirt2 Degrader-1 shows an IC50 of 0.25 μM for Sirt2, with no effect on Sirt1/Sirt3 (IC50s>100 μM).

dTRIM24 is a selective bifunctional degrader of TRIM24 based on PROTAC, consists of ligands for von Hippel-Lindau and TRIM24.

Homo-PROTAC pVHL30 degrader 1 is a potent pVHL30 degrader based on PROTAC, consists of two ligands of von Hippel-Lindau.

Fmoc-3VVD-OH is an intermediate for the synthesis of MMAE. The Fmoc protecting group may be removed with base, typically piperidine, to reveal the methylated N-terminal of this peptide.

Mal-amido-PEG3-NHS is a PEG linker featuring both an NHS ester and a maleimide. The NHS group is easily displaced by amine nucleophiles to form amides with target molecules while maleimide is a thiol-specific covalent linker which is used to label reduced cysteines in proteins.

Mal-amido-PEG5-NHS is a PEG linker featuring both an NHS ester and a maleimide. The NHS group is reactive with amine-containing molecules while maleimide is a thiol-specific covalent linker which is used to label reduced cysteines in proteins.