PEG

BS3 Crosslinker (disodium) is an aliphatic linker featuring two sulfo-NHS groups, which are readily displaced by amine nucleophiles to form amides with target molecules. Sulfo-NHS groups are more water-soluble than their NHS counterparts.

Di-tert-butyl iminodiacetate

N-(t-butyl ester-PEG4)-N-bis(PEG4-Propargyl) is a trifunctional PEG linker that combines a t-butyl ester with two terminal alkynes. The alkynes can be applied in copper-click chemistry with azides to form stable triazole linkages with a target molecule, while the t-butyl ester can be deprotected and reacted with amines or alcohols to form amides or esters.

N-(Acid-PEG4)-N-bis(PEG4-Propargyl) is a trifunctional PEG linker that combines a t-butyl ester with two terminal alkynes. The alkynes can be applied in copper-click chemistry with azides to form stable triazole linkages with a target molecule, while the acid can be reacted with amines or alcohols to form stable amides or esters.

DOPE-PEG-FITC, MW 2,000 is a PEG lipid combining a DOPE group and an FITC fluorescent dye. DOPE is a popular phospholipid in the field of lipid nanoparticle-based drug delivery. FITC is a green fluorophore with excitation and emission maxima at 491 nm and 516 nm respectively.

Mal-amido-PEG4-alkyne is a short PEG linker featuring a maleimide and a terminal alkyne. Maleimide is a covalent ligand used for linking thiols such as those in cysteines residues in proteins, while terminal alkynes can be used in copper (I) click chemistry with azides on target molecules.

DOPE-PEG-FITC, MW 5,000 is a PEG-lipid that features a DOPE phospholipid and an FITC fluorophore. DOPE is an unsaturated phospholipid that is commonly used to prepare lipid nanoparticles in drug delivery, while FITC is a green fluorophore with excitation and emission maxima at 491 nm and 516 nm respectively. FITC-PEG conjugates see frequent use in fluorescence microscopy, immunohistochemistry and other in vivo research applications.

N-(Acid-PEG8)-N-bis(PEG8-Azide) is a trifunctional molecule that combines two azide functions with a carboxylic acid via a tertiary amine at its center. The azides can be reacted with terminal alkynes or cyclooctynes to form stable triazoles with a target molecule. Meanwhile, the carboxylic acid can be coupled with amines using reagents such as HATU or EDC.

endo-BCN-PEG8-amine is a PEG linker featuring a BCN and a primary amine. The BCN group is a click chemistry handle which quickly reacts with azides while the primary amine can be used to form amides with carboxylic acids in the presence of coupling reagents such as HATU or EDC.