PEG

Benzyl-PEG-OH, MW 2,000 is a PEG reagent featuring a primary alcohol and a benzyl-protecting group. The alcohol is a versatile scaffold and can be manipulated in a variety of ways such as in creating esters or substituting with electrophiles such as halogens, mesylates, triflates, etc. The benzyl protecting group can be removed by hydrogenation to reveal a second alcohol group for further reactions.

N-(Boc-PEG4)-N-bis(PEG4-propargyl) is a trifunctional chemical containing two terminal alkynes and a Boc-protected primary amine. The terminal alkynes are used in copper click chemistry with azides to form stable triazole linkages with the target molecule while the carboxylic acids are reactive towards alcohols and primary amines to form esters and amides respectively.

Al-28 is a multi-ionizable aminolipid featuring a central amine and three identical disulfide-linked saturated side chains. The hydrophobic side chains are linked to the central structure by ester as well as disulfide bonds. Disulfide bonds are readily cleaved in the reducing environment of the cell cytoplasm. Ionizable lipids are typically used in the design of nucleic acid lipid nanoparticles, as their pH-dependent positive charge stabilizes the anionic nucleic acids they encapsulate.

N-(Amino-PEG4)-N-bis(PEG4-propargyl) HCl salt is a trifunctional linker with two terminal alkynes and a primary amine. The terminal alkynes can be linked to azides using copper click chemistry while the primary amine is reactive towards carboxylic acids, NHS esters, ketones and aldehydes to form a variety of stable bonds.

undecan-3-yl 8-bromooctanoate is a lipid featuring a bromide along an octanoate chain linking to a C11 chain. This molecule can be derivatized via substitution at the bromide leaving group.

NH-bis(PEG8-Acid) is a bifunctional reagent containing two carboxylic acids linked together by a secondary amine. The carboxylic acids are open for coupling with amines and alcohols to form amides and esters respectively while the secondary amine can be used as a nucleophile with ketones, aldehydes, and carboxylic acids. The PEG spacers make this molecule water-soluble, potentially altering its DMPK properties.

Linoleyl methane sulfonate is an unsaturated lipid molecule featuring a linoleyl chain and a mesylate leaving group that can easily be displaced by nucleophiles.

N6-Me-rA Phosphoramidite is a TBDMS-protected nucleoside phosphoramidite, which can be used to create oligonucleotides.

Thalidomide-O-PEG8-Amine, HCl salt is a PROTAC linker featuring a thalidomide ligand and a primary amine connected by a PEG chain. Primary amines readily form amides with carboxylic acids in the presence of coupling reagents. Thalidomide is a ligand for E3 ligase, which ubiquitinylates proteins, thus committing their fate to proteolytic destruction.