PEG

N-(Biotin-PEG23)-N-bis(PEG3-azide) is a branched biotinylation reagent for labeling. The azide group can react with alkyne, BCN, DBCO via Click Chemistry. Reagent grade, for research use only.

Thalidomide-5-(PEG8-Azide) is a PROTAC linker featuring a thalidomide ligand connected to a PEG spacer and an azide group. Azides are click chemistry handles that are capable of reacting with terminal alkynes or strained cyclooctynes. Thalidomide is a ligand for E3 ligase, which ubiquitinylates proteins, thus committing their fate to proteolytic destruction.

3,3'-[Dithiobis[2,1-ethanediyl(methylimino)]]bis[1-propanol] is a cleavable linker featuring two propanolamine headgroups connected by an S-S disulfide bond. This compound may be used to develop more complex amino lipids for lipid nanoparticle-based drug delivery.

m-PEG-Vinylsulfone, MW 5,000 is a large PEG linker with a methoxy cap and a vinylsulfone residue. The vinylsulfone group is a thiol-specific covalent ligand which is used for labeling proteins via the amino acid, cysteine. The methoxy cap is a relatively inert structure which allows PEGylation to selectively proceed on the vinylsulfone.

m-PEG-Vinylsulfone, MW 20,000 is a large PEG linker with a methoxy cap and a vinylsulfone residue. The vinylsulfone group is a thiol-specific covalent ligand which is used for labeling proteins via the amino acid, cysteine. The methoxy cap is a relatively inert structure which allows PEGylation to selectively proceed on the vinylsulfone.

bis-Vinylsulfone-PEG, MW 5,000 is a large PEG reagent featuring two vinylsulfone groups. Vinylsulfone is a cysteine-specific covalent linker that is used to label proteins. PEG crosslinking is well-known to increase the aqueous solubility of the final conjugate and alter ADME.

m-PEG-Glu-Glutamic acid, MW 20,000 is a large PEG linker with a methoxy cap and a bis(glutamic acid) dipeptide. The methoxy cap is relatively inert, allowing any reactivity to occur at the glutamic acid residues. The glutamic acid dipeptide features three carboxylic acids which can be used to build larger conjugates via amide or ester bonds.

PLA(2.5k)-mPEG(5k) is a PEG-PLA copolymer featuring a methoxy cap. Poly(D, L lactide) is a hydrophobic polymer which, when combined with the hydrophilic PEG, is capable of self-assembling into micelles in aqueous media. This copolymer can be used to prepare nanoparticles for use in drug delivery.

m-PEG-Phosphate, MW 5,000 is a PEG linker containing a methoxy cap and a terminal phosphate group. Phosphates can be used to link with alcohols to form phosphodiester bonds such as those found in nucleic acids and phospholipids.