PEG

m-PEG-Iodoacetamido, MW 5,000 is a PEG linker featuring a methoxy cap and an iodoacetamide group. Iodoacetamide is a covalent ligand used in binding thiols such as those featured in the amino acid cysteine. The methoxy cap is fairly inert, allowing conjugation to selectively occur at the iodoacecetamide.

m-PEG-Propionic acid, MW 5,000 is a PEG linker with a methoxy cap and a carboxylic acid. The carboxylic acid is readily used to create amides and esters with amines or alcohols, while the methoxy cap is unreactive and allows PEGylation to selectively proceed at the carboxylic acid.

m-PEG-Hexanoic acid, MW 5,000 is a PEG linker with a methoxy cap and a carboxylic acid. The carboxylic acid is readily used to create amides and esters with amines or alcohols, while the methoxy cap is unreactive and allows PEGylation to selectively proceed at the carboxylic acid.

bis-Propargyl-PEG, MW 5,000 is a PEG reagent featuring two terminal alkynes. These alkyne groups are most often used in copper (I) click chemistry with azide-containing molecules to create stable triazole links between the two compounds.

N-(Amide-Propargyl)-N-bis(m-PEG3), MW 40,000 is a PEG linker consisting of two mPEG spacers and a terminal alkyne joined together by a central tertiary amide. The propargyl group is a terminal alkyne which is used in copper click chemistry with azide groups to create a stable triazole linkage with a target molecule. The mPEG spacers are fairly inert structures which increase the aqueous solubility of the final conjugate.

m-PEG-Aldehyde, MW 30,000 is a PEG reagent featuring a methoxy cap and an aldehyde group. Aldehydes are strong electrophiles which are frequently used in reductive aminations to form stable secondary amines, while the methoxy cap is chemically inert so as to restrict reactivity to the aldehyde group.

Azido-PEG8-4-nitrophenyl carbonate is a PEG linker featuring an azide and a nitrophenyl carbonate. Azides are click chemistry handles that can react with terminal alkynes or strained cyclooctynes while the nitrophenyl is a good leaving group that is easily displaced by amines to form carbamates.

N-(Mal-PEG8-carbonyl)-N-bis(PEG8-NHS ester) is a trifunctional linker containing two activated NHS esters and a maleimide group. The NHS esters are strongly reactive towards forming amides and esters while the maleimide is a thiol-specific covalent ligand that is most often used to label cysteine residuess along protein chains. The use of a tertiary amide as the junction combining these allows for hydrogen bonding and increases this compound’s aqueous solubility.

N-(DBCO-PEG4-carbonyl)-N-bis(PEG4-acid) is a reagent combining two carboxylic acids and a DBCO moiety. The carboxylic acids can be reacted with primary amines in the presence of an activator such as HATU or EDC to form stable and water-soluble amide bonds, while the DBCO moiety is used in click chemistry with azides. The inclusion of a tertiary amide and PEG linkers improves this molecule’s aqueous solubility.