PEG

N-(DBCO-PEG4-carbonyl)-N-bis(PEG4-NHS ester) is a chemical linker that contains two NHS esters and a DBCO group. DBCO is a strained cyclooctyne that is used in a click reaction with azides to form stable triazole links, while the NHS esters are highly activated towards reactions with amines and alcohols. The use of a tertiary amide increases the water solubility of this compound.

1,1'-[2-(methyl 6-bromohexanoate)-1,3-propanediyl] dilinoleate is a branched lipid component featuring three ester-linked side chains, two linoleic acyl groups and a bromohexanoate. This compound may be used to develop more complex lipids via bromide substitution.

N-(Mal-PEG4-carbonyl)-N-bis(PEG4-acid) is a bifunctional reagent with two carboxylic acids and a maleimide group. Maleimide is a thiol-specific covalent ligand that is often used in labeling proteins, while the carboxylic acids are open for reaction with primary amines to form amide bonds. PEG linkers are highly water soluble but the inclusion of an amide bond makes this molecule especially so.

Fmoc-PEG9-alcohol is a heterobifunctional PEG linker featuring a Fmoc-protected primary amine and an alcohol group. The hydroxy group is a versatile functionality while the Fmoc protecting group can be removed with base to reveal a primary amine.

N-(azide-PEG10)-N-(PEG10-N-boc)-N-(PEG10-t-butyl ester) is a trifunctional PEG linker with an azide, a Boc-protected amine, and a t-butyl ester. The azide can be used in click chemistry with terminal alkynes and strained cyclooctynes like DBCO or BCN. t-Butyl esters can be deprotected using acidic or basic conditions to allow for amide coupling or esterification. Finally the Boc-protecting group can be removed with acid, allowing the primary amine to engage in reactions with carboxylic acids, aldehydes or ketones to form stable bonds with other molecules.

3-(PEG4-Azide)-2-((PEG4-Azide)methyl)propan-1-ol is a trifunctional linker with two azides and a primary alcohol group. The azides are applied in click chemistry with terminal alkynes and strained cyclooctynes like DBCO and BCN while the alcohol can be used in numerous ways such as forming esters with carboxylic acids. The use of a PEG linker provides this molecule with aqueous solubility.

2,2-Di(9Z,12Z)-9,12-octadecadien-1-yl-1,3-dioxolane-4-ethanol is a lipid linker featuring two polyunsaturated chains linked to an acetal and a primary alcohol. The hydroxy group can be used to expand the structure. This compound may be utilized to develop more complex lipids for drug delivery.

2-(2,6-Dioxopiperidin-3-yl)-4-nitroisoindoline-1,3-dione is a nitrosylated thalidomide analogue. Thalidomide is a ligand for E3 ligase, which ubiquitinylates proteins, thus committing their fate to proteolytic destruction.

2-(2,6-dioxopiperidin-3-yl)-5-nitroisoindoline-1,3-dione is a E3 ligase activator, used for proteolytic destruction of proteins.