PEG

2-(2,6-dioxo-3-piperidyl)-4-[2-(2-hydroxyethoxy)ethylamino]isoindoline-1,3-dione is a PROTAC linker featuring a pomalidomide, a hydrophilic PEG spacer, and an alcohol. Pomalidomide is an E3 Ligase activator, which promotes proteolysis of target proteins via ubiquitinylation. This structure features a hydroxy group which may be used for further derivatization.

Pomalidomide 4'-alkylC8-amine, HCl salt is a PROTAC linker featuring a pomalidomide, an aliphatic hexyl spacer, and a primary amine. Pomalidomide is a ligand for E3 ligase, which ubiquitinylates proteins. Meanwhile, the amine may be used for further derivitization through a number of different reactions.

Thalidomide-NH-PEG3-COOH is a PROTAC linker featuring a thalidomide, a hydrophilic PEG spacer, and a carboxylic acid. Thalidomide is a ligand for E3 ligase, which recruits proteins for proteolytic destruction. This structure features a carboxylic acid whcih may be used for further derivatization through reactions with amines or alcohols.

dCBP-1 is a potent and selective heterobifunctional degrader that utilizes a Cereblon ligand. Notably, it exhibits exceptional potency in eliminating multiple myeloma cells.

2-{[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl]oxy}acetic acid is an E3 Ligase activator featuring a carboxylic acid which may be used for further derivatization.

4-Hydroxy-2-(1-methyl-2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione is a thalidomide analogue featuring an alcohol. Thalidomide is a ligand for E3 ligase, which ubiquitinylates proteins, thus committing their fate to proteolytic destruction.

t-butyl-ester-PEG4-(CH2)3OH is a PEG linker with a terminal hydroxyl group which may be further derivatized. The t-butyl protected carboxyl group can be deprotected under acidic conditions. The hydrophilic PEG spacer increases solubility in aqueous media.

Pomalidomide-amino-PEG4-NH2 hydrochloride is a PROTAC linker featuring a pomalidomide, a PEG spacer and a primary amine. Pomalidomide activates E3 ligase to ubiquinylate target proteins. This structure's amine may be used for further derivatization through a variety of reactions.

PROTAC BET Degrader-10 is a potent BET protein BRD4 degrader that targets BET proteins for PROTAC research purposes.