PEG

SJ6986

PROTAC B-Raf degrader 1 (compound 2) is a proteolysis targeting chimera (PROTAC) for the degradation of B-Raf based on Cereblon ligand with anti-cancer activity.

CCT367766

Thalidomide-4-C3-NH2, HCl salt is a PROTAC linker featuring a thalidomide analogue, an aliphatic hexyl spacer, and a primary amine. This molecule is an activator of E3 ligase, which ubiquitinylates proteins for subsequent proteolysis. This structure's amine may be used for further derivatization through a variety of reactions.

Pomalidomide 4'-alkylC8-acid is a functionalized cereblon ligand for PROTAC research and development; incorporates an E3 ligase ligand plus an alkylC8 linker with terminal acid ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D.

2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindole-5-carbaldehyde is a thalidomide analogue with an aldehyde. Thalidomide recruiits E3 ligase for the ubiquitinylation and subsequent proteolysis of target proteins. The aldehyde is highly reactive towards amine nucleophiles through reductive amination among other reactions.

2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindole-4-carbaldehyde is a thalidomide analogue with an aldehyde. Thalidomide recruiits E3 ligase for the ubiquitinylation and subsequent proteolysis of target proteins. The aldehyde is highly reactive towards amine nucleophiles through reductive amination among other reactions.

5-bromo-2-(2,6-dioxopiperidin-3-yl)-6-fluoro-2,3-dihydro-1H-isoindole-1,3-dione is a thalidomide analogue. This molecule is an activator of E3 ligase, which ubiquitinylates proteins for proteolysis. The structure may be further derivatized via substitution at fluorine or bromine.

5,6-dichloro-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione is a thalidomide analogue. This molecule is an activator of E3 ligase, which ubiquitinylates proteins. The structure may be further derivatized via substitution at chlorine.