PEG

Methyltetrazine-amido-PEG8-alkyne is a PEG linker with two click chemistry handles, a methyltetrazine and a terminal alkyne. Methyltetrazines rapidly react with TCO groups while terminal alkynes are used in copper (I) click chemistry with azides.

Mal-PEG4-Val-Cit-PAB-MMAE is a cleavable ADC linker featuring a maleimide, a Val-Cit dipeptide, a PAB group, and an MMAE toxin. Maleimide is a thiol-specific covalent linker which is used to conjugate cysteine residues in proteins while the Val-Cit dipeptide is a protease-cleavable motif which releases the MMAE warhead into cells via an elimination mechanism.

Amino-PEG8-C3-alcohol is a PEG linker with a terminal amino group which is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde), etc. Hydroxyl group can react with a variety of functional groups. PEG spacer improves the aqueous solubility of the compound.

9Z-tetradecenoic acid

Amino-PEG4-C3-alcohol is a PEG linker with a terminal amino group that can react with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde), etc. Hydroxyl group can react with a variety of functional groups. PEG spacer improves the compound's aqueous solubility.

Chloride-C3-PEG8-acid contains a chloride atom for substitution reactions and a terminal acid group to react with amine-bearing molecules in the presence of activators (e.g. HATU). The hydrophilic PEG units increase hydrophilicity.

Methyltetrazine-PEG7-alkyne is a PEG linker with two click chemistry handles: a methyltetrazine and a terminal alkyne. Methyltetrazines rapidly react with TCO groups while terminal alkynes are used in copper (I) click chemistry with azides.

DOPE-PEG-BDP FL, MW 5,000 is a PEG-lipid-dye conjugate with a DOPE phospholipid and a BDP FL fluorophore linked together by a large PEG spacer. DOPE is an unsaturated phospholipid used often in the construction of lipid nanoparticles while BDP FL is a fluorescent dye featuring excitation and emission maxima at 504 and 514 nm respectively.

Cbz-N-amido-PEG8-bromide contains a Cbz-protected amino group and a terminal bromide group for substitution reactions. The Cbz protecting group can be removed under acidic conditions to free the amine, which can react with carboxylic acid or efficiently with activated NHS ester.