PEG

N-(NHS ester-PEG4)-N-bis(PEG4-azide) functions as a branched linker containing two azides and a terminal NHS ester. The azide is reactive towards strained cyclooctynes and other alkynes using click chemistry. The NHS ester is able to react specifically and efficiently with amines (e.g. the side chain of lysine residues or aminosilane-coated surfaces). PEG linkers provide high aqueous solubility, and altering PEG length can alter DMPK.

Methyltetrazine-amido-PEG8-amine, TFA salt is a heterobifunctional linker containing a terminal methyltetrazine, which can react with TCO-containing compounds without the catalysis of Cu or elevated temperatures, and terminal amine, which reacts with NHS ester specifically and efficiently. The PEG spacer enhances water solubility.

4-Methyl-1-piperazinepentanoic acid

DSPE-PEG-alkyne, MW 2,000 is a lipid PEG with a hydrophilic phosphate head with hydrophobic lipid tails. The molecule can self-assemble in water to form lipid bilayer with hydrophobic tails facing the inner area and hydrophilic head facing outward interacting with water. The compound can be used to prepare nanoparticles or liposomes as drug nanocarriers to deliver therapeutics, such as mRNA/DNA vaccine. The alkyne group enables click reaction with azido molecules in the presence of Cu catalyst.

Hydroxy-PEG-t-butyl ester, MW 5,000 is a polyPEG linker with a primary alcohol group that can be be derivatized and a t-butyl group that can be deprotected under acidic conditions. The PEG chain helps with water solublity and flexibilty of the crosslinking agent.

NH-bis(PEG4-azide) is a PEG linker with two terminal azide moities for effortless interaction with DBCO, BCN, or related alkynes using click chemistry and an amine located in the center of the molecule. The PEG spacer improves water solublity.

DSPE-PEG-Fluor 647, MW 5,000 is a bright green-fluorescent dye consisting of a PEG 5k spacer between the hydrophilic phosphate head and hydrophobic lipid tails. The dye is water soluble and pH-insensitive from pH 4 to pH 10. It has 4 sulfonate groups, making it more hydrophilic and less aggregating in aqueous solutions. The polymer can self-assemble to form lipid bilayer in water.

Amine-PEG-Amide-PEG5-Propargyl, MW 5,000 TFA salt is a heterobifunctional polyPEG linker with a ready-to-conjugate terminal amine and propargyl that can participate in copper catalyzed azide-alkyne Click Chemistry.

(S, R, S)-AHPC-PEG12-amine is a synthetic PROTAC linker molecule that incorporatess an E3 ligase ligand linked to a PEG spacer to empower PROTAC drug research & discovery. The hydrophilic PEG spacer increases the solubility of the compound in aqueous media.