PEG

DBCO-PEG4-Desthiobiotin is a polyethylene glycol (PEG) derivative utilized as a linker for the synthesis of proteolysis-targeting chimeras (PROTACs)[1].

DBCO-SS-PEG4-Biotin, a cleavable, mid-functional ADC linker with a 4-unit PEG moiety, is used in the synthesis of antibody-drug conjugates (ADCs)[1].

N-(Azide-PEG3)-N'-(PEG4-NHS ester)-Cy5 is a polyethylene glycol (PEG)-derived PROTAC linker, used in the synthesis of PROTACs [1].

PC Azido-PEG23-NHS carbonate ester functions features an amine-reactive NHS ester connected to a terminal azide via a photocleavable linker and PEG linker. This structure allows for efficient photorelease of linked molecules, typically achieving over 90% cleavage in 5-25 minutes using a near-UV lamp. The azido can participate in copper-catalyzed Click Chemistry reactions with alkynes, DBCO, and BCN. The NHS labels the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-bearing molecules. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

PC Azido-PEG7-NHS carbonate ester constitutes a photocleavable PEG linker featuring an azido moiety for copper-catalyzed click chemistry with alkyne, DBCO, BCN, and NHS carbonate ester to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. This structure allows for efficient photorelease of linked molecules, typically achieving over 90% cleavage in 5-25 minutes using a near-UV lamp

Lulizumab pegol (BMS-931699) is an anti-CD28 antibody antagonist that inhibits T-cell proliferation, offering potential therapeutic applications for kidney transplantation and autoimmune disease research [1].

Azido-PEG3-maleimide is a PEG-based PROTAC linker used primarily for the synthesis of PROTACs[1] and also functions as a cleavable 3-unit PEG ADC linker in the synthesis of antibody-drug conjugates (ADCs)[2].

endo-BCN-PEG8-acid, a PEG-based linker, is pivotal for PROTAC molecules, connecting two essential ligands and facilitating selective protein degradation via the ubiquitin-proteasome system within cells.

Biotin-PEG-Biotin (MW 1000) is a PEG-derived PROTAC linker utilized in PROTAC synthesis [1].