PEG

3-(1-Oxo-6-piperazin-1-yl-isoindolin-2-yl)piperidine-2,6-dione

Cis VH032 amine dihydrochloride is a VHL ligand useful for regulating hypoxia signaling pathways and investigating conditions like chronic anemia or ischemia.

BWA-522 intermediate-1 is a key component in the synthesis of PROTAC BWA-522, acting as a ligand for cereblon E3 ubiquitin ligase. It plays a role in targeting specific proteins for degradation.

SJ995973 is a potent PROTAC molecule designed to degrade bromodomain and extra-terminal (BET) proteins, targeting key structural domains for protein degradation.

SNX7886 is a potent PROTAC designed to selectively degrade CDK8 and CDK19 proteins, effectively targeting these kinases in cellular systems.

DB1113 is a bifunctional compound designed for targeted protein degradation of various kinases. It effectively mediates the degradation of multiple kinase targets, facilitating the study of processes related to dysregulated kinase activity.

SJ1008030 TFA is a PROTAC specifically designed to target and degrade JAK2. This compound demonstrates selective inhibition of cell growth in MHH–CALL-4 cells, making it useful for studying mechanisms related to leukemia.

LC-MB12 is an orally active PROTAC designed for the degradation of FGFR2. This compound integrates a FGFR2 inhibitor, a PROTAC linker, and a cereblon-binding moiety, effectively disrupting FGFR2 signaling in gastric cancer cells. Its structural components facilitate targeted protein degradation, highlighting its potential in research focused on tumor biology.

PROTAC GPX4 degrader-1 (DC-2) is a PROTAC designed for the targeted degradation of GPX4. This compound employs a structure that facilitates the selective elimination of GPX4, highlighting its utility in studies related to oxidative stress and cellular regulation.