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KTX-582 is a potent PROTAC targeting the degradation of IRAK4 and Ikaros. It promotes apoptosis in MYD88 mutant cell lines and demonstrates efficacy in inducing tumor regression in lymphoma models.

YD23 is a PROTAC molecule designed to target and degrade SMARCA2, exploiting the synthetic lethality with SMARCA4. It modulates chromatin accessibility, particularly at gene enhancers involved in cell cycle and growth regulation, with selective effects in SMARCA4-deficient cells.

MS4322 isomer is an isomer of a selective PRMT5 degrader, designed to target and degrade protein arginine methyltransferase 5. Its activity includes inhibiting the growth of various cell lines, highlighting its role in modulating PRMT5-related processes.

PROTAC IDO1 Degrader-1 is a bifunctional molecule designed to target indoleamine 2,3-dioxygenase 1 (IDO1) for degradation by recruiting it to the Cereblon E3 ligase, leading to its ubiquitination and subsequent breakdown via the ubiquitin-proteasome system. It has been shown to enhance the activity of certain immune cells in a research context.

Setidegrasib is a quinazoline-linked (4R)-4-hydroxy-L-prolinamide-based PROTAC designed to target and degrade the G12D-mutant KRAS protein. Its structure enables selective recruitment of the mutant protein for proteasomal degradation.

ARD-61 is a highly potent and selective PROTAC designed to degrade androgen receptors (AR) and progesterone receptors (PR) in AR-positive cell lines. It contains an alkyne group, allowing for copper-catalyzed azide-alkyne cycloaddition (CuAAC), making it useful for click chemistry applications.

SJ988497 is a PROTAC molecule designed to degrade JAK2, effectively inhibiting cell proliferation in CRLF2-rearranged cell lines. It also promotes the degradation of the CRBN neosubstrate GSPT1. Structurally, it includes a Ruxolitinib derivative, a linker, and a CRBN ligand (Pomalidomide), making it useful for studying protein degradation mechanisms.

ZXH-4-130 is a potent and selective degrader of CRBN, functioning as a hetero-PROTAC compound that connects CRBN and VHL. Its structure facilitates targeted protein degradation. The salt form, ZXH-4-130 TFA, offers improved water solubility and stability compared to its free form, while maintaining similar biological activity.

PROTAC BRAF-V600E degrader-1 is a highly effective compound designed to target and degrade the BRAF-V600E protein through the ubiquitin-proteasome system (UPS). Its structure allows for selective binding to both BRAF and the BRAF-V600E variant, facilitating protein degradation.