PEG

dTAG-47 is a heterobifunctional compound designed to target the mutant FKBP12, which functions as a degradation tag when fused to a protein of interest. This unique structure facilitates targeted protein degradation, making it a valuable tool for investigating basal-like breast cancers. Its bifunctional nature enhances selectivity and efficacy in protein modulation studies.

FC-11 is a PROTAC that targets focal adhesion kinase (FAK) for degradation. It features a Cereblon ligand from Pomalidomide, a linker, and a FAK ligand, PF562271. This compound effectively degrades FAK in various cell types, making it a useful tool for studying FAK-related signaling pathways.