PEG

Bis-sulfone-PEG4-DBCO constitutes a PEG linker with a sulfone and DBCO end group. The sulfone group can be conjugated with thiol groups of proteins. The terminal DBCO can react with azides through copper-free catalyzed click chemistry. The hydrophilic PEG chain increases the water solubility of the compound in aqueous media.

A useful synthetic scaffold consisting of two cis-2-noneyl esters and a free hydroxyl head group which may be further functionalized into an ionizable head group. Reagent grade, for research purpose. Please contact us for GMP-grade.

Methyltetrazine-PEG4-Sulfo DBCO constitutes a heterobifunctional PEG linker with a methyltetrazine click chemistry handle that rapidly ligates to trans-cyclooctene (TCO) groups on target molecules and DBCO click chemistry handle that undergoes copper-free reactions with azides. The PEG arm improves the solubility of the compound in aqueous media.

DLinDAP is an ionizable lipid featuring a dimethylamine head group and two biodegrable ester linkages to linoleic acid tails. This compound may be formulated into lipid nanoparticles for mRNA delivery applications. Reagent grade, for research purpose. Please contact us for GMP-grade.

DOTA-PEG3-Methyltetrazine, HCl salt represents a PEG linker including a DOTA group that can be ionized and is susceptible to chelating di- and trivalent cations. DOTA can also be used for imaging diagnostic techniques. Methyltetrazine can be used to react with TCO via click chemistry. The PEG spacer increases the water-solubility.

DOTA-PEG4-alkyne functions as a PEG linker consisting of a DOTA group that can be ionized and chelates di- and trivalent cations. DOTA is also useful in imaging diagnostics. The alkyne reacts with azides via a copper-catalyzed click reaction (CuAAC).

Sulfo-Cy5.5 tyramide is integral to tyramide signal amplification (TSA), enhancing fluorescent signals in immunohistochemistry (IHC), immunocytochemistry (ICC), and fluorescence in situ hybridization (FISH). Utilizing horseradish peroxidase (HRP), it converts tyramine-containing substrates into reactive radicals. This enables the detection of low-concentration targets and reduces background staining without compromising signal intensity. Sulfo-Cy5.5 tyramide can be used with HRP-conjugated molecules, such as antibodies or streptavidin, for immunofluorescence staining of cells and tissues.

Sulfo-Cy7 tyramide is crucial for enhancing fluorescent signals via tyramide signal amplification (TSA) in immunohistochemistry (IHC), immunocytochemistry (ICC), and fluorescence in situ hybridization (FISH). Through horseradish peroxidase (HRP), it converts tyramine-containing substrates into reactive radicals. This enables the detection of low-concentration targets and reduces background staining without compromising signal intensity. Sulfo-Cy7 tyramide can be used with HRP-conjugated molecules, such as antibodies or streptavidin, for immunofluorescence staining of cells and tissues.

DREADD agonist 21 selectively activates hM3Dq and hM4Di DREADDs, derived from the human muscarinic acetylcholine M3 (hM3) receptor, without affecting the hM3 receptor itself. It has weaker affinities for other receptors (histamine H1, serotonin 5-HT2A, 5-HT2C, and α1A-adrenergic). Used in chemogenetics, it remotely controls neuronal activity, permeates the brain effectively, activating hM3Dq and inhibiting hM4Di DREADDs in vivo. This dihydrochloride salt formulation ensures water solubility.