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    Results for Chemicals ( 21749 )

      • PROTAC Bcl2 degrader-1

        Ref: T10485
        Sizes: 1 mg, 5 mg, 10 mg
        Price Enquiry

        PROTAC Bcl2 degrader-1 (Legacy Tebubio ref. 282T10485). PROTAC Bcl2 degrader-1 is a PROTAC, which potently and selectively induces the degradation of Mcl-1 (IC50: 11.81 μM) and Bcl-2 (IC50: 4.94 μM; DC50: 3.0 μM).

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      • CDK ligand for PROTAC hydrochloride

        Ref: T10734L
        Sizes: 5 mg, 25 mg, 100 mg, 50 mg, 10 mg, 1 mL * 10 mM (in DMSO)
        Price Enquiry

        CDK ligand for PROTAC hydrochloride (Legacy Tebubio ref. 282T10734L). CDK ligand for PROTAC hydrochloride is a CDK inhibitor with antitumor activity. It has been used to design PROTAC CDK4/6 degraders.

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      • HaloPROTAC3

        Ref: T32043
        Sizes: 1 mg, 5 mg, 25 mg, 100 mg, 50 mg, 10 mg
        From: €128.00

        HaloPROTAC3 (Legacy Tebubio ref. 282T32043). HaloPROTAC3 (HaloPROTAC-3) is a conjugate of ligands for E3 and 16-atom-length linker and a degrader of HaloTag fusion proteins.

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      • PROTAC BRD4 Degrader-5

        Ref: T36242
        Sizes: 1 mg, 5 mg, 25 mg, 50 mg, 10 mg, 1 mL * 10 mM (in DMSO)
        Price Enquiry

        PROTAC BRD4 Degrader-5 (Legacy Tebubio ref. 282T36242). PROTAC BRD4 Degrader-5 is a PROTAC that efficiently degrades BRD4 in HER2-positive and -negative breast cancer cell lines, and is formed by linking von Hippel-Lindau ligand to BRD4 ligand.

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      • PROTAC RIPK degrader-6

        Ref: T36243
        Sizes: 5 mg, 25 mg, 10 mg, 1 mL * 10 mM (in DMSO)
        Price Enquiry

        PROTAC RIPK degrader-6 (Legacy Tebubio ref. 282T36243). PROTAC RIPK degrader-6 (example 1) is a PROTAC engineered for RIP Kinase degradation, comprising a RIP2 kinase inhibitor linked to a cereblon binder[1].

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      • TBK1 control PROTAC® 4

        Ref: T36247
        Sizes: 5 mg
        From: €1,215.00

        TBK1 control PROTAC® 4 (Legacy Tebubio ref. 282T36247). Negative control for TBK1 PROTAC 3i. Binds TBK1 with high affinity, but exhibits no significant degradation of TBK1. PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license.

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      • PROTAC BRD4 Degrader-8

        Ref: T36628
        Sizes: 1 mg, 5 mg
        Price Enquiry

        PROTAC BRD4 Degrader-8 (Legacy Tebubio ref. 282T36628). PROTAC BRD4 Degrader-8 is a potent BRD4 inhibitor with IC50 values of 1.1 nM and 1.4 nM for BRD4 BD1 and BD2, respectively, effectively degrading the BRD4 protein in PC3 prostate cancer cells[1].

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      • PROTAC IDO1 Degrader-1

        Ref: T37329
        Sizes: 5 mg
        Price Enquiry

        PROTAC IDO1 Degrader-1 (Legacy Tebubio ref. 282T37329). PROTAC IDO1 Degrader-1, a pioneering compound, efficiently targets indoleamine 2,3-dioxygenase 1 (IDO1) for ubiquitination and degradation by recruiting IDO1 to the CRBN E3 ligase, thereby facilitating its entry into the ubiquitin-proteasome system (UPS) with a DC50 of 2.84 μM. This compound also moderately enhances the tumor-killing efficacy of HER2 CAR-T cells[1].

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      • PROTAC BET Degrader-10

        Ref: T39374
        Sizes: 5 mg, 25 mg, 100 mg, 50 mg, 10 mg, 1 mL * 10 mM (in DMSO)
        Price Enquiry

        PROTAC BET Degrader-10 (Legacy Tebubio ref. 282T39374). PROTAC BET Degrader-10 (WO2017007612A1, example 37) is a highly efficient and selective small molecule compound designed to degrade BET protein BRD4. PROTAC BET Degrader-10 functions by utilizing specific ligands that connect Cereblon and BRD4, with a DC 50 value of 49 nM.

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