Other Proteins

Recombinant Human IL-12 p70 (CHO derived) (Legacy Tebubio ref. 167200-12). IL-12 is a potent regulator of cell-mediated immune responses and it induces IFN-gamma production by NK and T cells. It is produced by activated monocytes/macrophage cells, B lymphocytes and connective tissue-type mast cells. Among its biological activities, IL-12 promotes the growth and activity of activated NK, CD4+ and CD8+ cells, and induces the development of IFN-gamma-producing Th1 cells. Recombinant Human IL-12 is a 75.0 kDa heterodimeric glycoprotein consisting of disulfide-linked 35 kDa (p35) and 40 kDa (p40) subunits (503 total amino acid residues).

Recombinant Human IL-12 p70 (CHO derived) (Legacy Tebubio ref. 167200-12). IL-12 is a potent regulator of cell-mediated immune responses and it induces IFN-gamma production by NK and T cells. It is produced by activated monocytes/macrophage cells, B lymphocytes and connective tissue-type mast cells. Among its biological activities, IL-12 promotes the growth and activity of activated NK, CD4+ and CD8+ cells, and induces the development of IFN-gamma-producing Th1 cells. Recombinant Human IL-12 is a 75.0 kDa heterodimeric glycoprotein consisting of disulfide-linked 35 kDa (p35) and 40 kDa (p40) subunits (503 total amino acid residues).

Recombinant Human IL-12 p70 (HEK293 derived) (Legacy Tebubio ref. 167200-12H). IL-12 is a potent regulator of cell-mediated immune responses and it induces IFN-gamma production by NK and T cells. It is produced by activated monocytes/macrophage cells, B lymphocytes and connective tissue-type mast cells. Among its biological activities, IL-12 promotes the growth and activity of activated NK, CD4+ and CD8+ cells, and induces the development of IFN-gamma-producing Th1 cells. PeproTech's Recombinant Human IL-12 p70, derived from HEK293 cells, is a heterodimeric glycoprotein consisting of disulfide-linked p35 and p40 subunits (503 total amino acid residues). The calculated molecular weight of Human IL-12 p70 is 57.2 kDa; however, due to glycosylation, it migrates at an apparent molecular weight of 65-70 kDa based on SDS-PAGE gel, under non-reducing conditions.

Recombinant Human IL-12 p70 (HEK293 derived) (Legacy Tebubio ref. 167200-12H). IL-12 is a potent regulator of cell-mediated immune responses and it induces IFN-gamma production by NK and T cells. It is produced by activated monocytes/macrophage cells, B lymphocytes and connective tissue-type mast cells. Among its biological activities, IL-12 promotes the growth and activity of activated NK, CD4+ and CD8+ cells, and induces the development of IFN-gamma-producing Th1 cells. PeproTech's Recombinant Human IL-12 p70, derived from HEK293 cells, is a heterodimeric glycoprotein consisting of disulfide-linked p35 and p40 subunits (503 total amino acid residues). The calculated molecular weight of Human IL-12 p70 is 57.2 kDa; however, due to glycosylation, it migrates at an apparent molecular weight of 65-70 kDa based on SDS-PAGE gel, under non-reducing conditions.

Recombinant Human sIL-12 Receptor beta-1 Fc (Legacy Tebubio ref. 167200-12RB-1). The IL‐12 structurally related family of heterodimeric proteins plays an important role in activating, regulating, and modulating the immune response. This family of proteins transmits its activity through receptors, which, when stimulated by ligand binding, generally activate JAK proteins that subsequently phosphorylate STAT transcription factors. IL‐12R beta‐1 is a single pass membrane protein expressed on T cells, B cells, and NK cells. By itself, IL‐12R beta‐1 binds to IL‐12 with low affinity, but when paired with IL‐12R beta‐2, forms a high affinity IL‐12 receptor. IL‐12R beta‐1 can also pair with IL‐23R to form a high affinity receptor for IL‐23. Recombinant Human sIL‐12 Receptor beta‐1 Fc has a calculated molecular weight of 84.3 kDa and contains 758 amino acid residues, which consists of the extracellular domain of IL‐12R beta‐1 fused to the Fc portion of human IgG and contains a C‐terminal His‐tag

Recombinant Human sIL-12 Receptor beta-1 Fc (Legacy Tebubio ref. 167200-12RB-1). The IL‐12 structurally related family of heterodimeric proteins plays an important role in activating, regulating, and modulating the immune response. This family of proteins transmits its activity through receptors, which, when stimulated by ligand binding, generally activate JAK proteins that subsequently phosphorylate STAT transcription factors. IL‐12R beta‐1 is a single pass membrane protein expressed on T cells, B cells, and NK cells. By itself, IL‐12R beta‐1 binds to IL‐12 with low affinity, but when paired with IL‐12R beta‐2, forms a high affinity IL‐12 receptor. IL‐12R beta‐1 can also pair with IL‐23R to form a high affinity receptor for IL‐23. Recombinant Human sIL‐12 Receptor beta‐1 Fc has a calculated molecular weight of 84.3 kDa and contains 758 amino acid residues, which consists of the extracellular domain of IL‐12R beta‐1 fused to the Fc portion of human IgG and contains a C‐terminal His‐tag

Recombinant Human IL-12 p80 (Legacy Tebubio ref. 167200-12p80H). IL-12 is a disulfide-linked heterodimeric protein (p70), composed of two subunits, p35 and p40, which are encoded by two different genes. Accumulating data indicates that p40 secretion precedes that of IL-12 expression. In addition, to its ability to covalently bind to p35 to form IL-12, p40 can bind to p19 to form IL-23, or it can form the homodimer designated IL-12 p80. Elevated levels of IL-12 p80 correlate to macrophage recruitment and increased inflammation in asthma and respiratory viral infection models. Recombinant Human IL-12 p80 is an 80.0 kDa disulfide linked homodimer consisting of two p40 chains of IL-12.

Recombinant Human IL-12 p80 (Legacy Tebubio ref. 167200-12p80H). IL-12 is a disulfide-linked heterodimeric protein (p70), composed of two subunits, p35 and p40, which are encoded by two different genes. Accumulating data indicates that p40 secretion precedes that of IL-12 expression. In addition, to its ability to covalently bind to p35 to form IL-12, p40 can bind to p19 to form IL-23, or it can form the homodimer designated IL-12 p80. Elevated levels of IL-12 p80 correlate to macrophage recruitment and increased inflammation in asthma and respiratory viral infection models. Recombinant Human IL-12 p80 is an 80.0 kDa disulfide linked homodimer consisting of two p40 chains of IL-12.

Recombinant Human sIL-15 Receptor alpha Fc (Legacy Tebubio ref. 167200-15RA). IL‐15 signaling is an important factor in proliferating, activating, and immunomodulating primarily T cells. IL‐15R alpha is an IL‐15 specific, single pass membrane receptor which complexes with IL‐2R beta and IL‐2R gamma to form a high affinity IL‐15 receptor. Additionally, the IL‐15/IL‐15R complex is capable of binding to IL‐2 beta/gamma receptors on other cells, therefore enabling IL‐15 to indirectly activate cells expressing IL‐2 beta/gamma receptors. A soluble form of IL‐15 receptor alpha is naturally produced by proteolytic cleavage of the membrane‐bound precursor. This naturally occurring soluble form can act as a modulator of IL‐15 signaling through the inhibition of IL‐15 receptor binding. Recombinant Human sIL‐15 Receptor alpha Fc has a calculated molecular weight of 44.4 kDa protein and contains 408 amino acid residues, which consists of the extracellular domain of IL‐15R alpha fused to the Fc port