Other Proteins

LKB1 (STK11) is a member of the serine/threonine kinase family which regulates cell polarity and functions as a tumor suppressor. STK11 is a critical barrier to pulmonary tumorigenesis which controlling initiation, differentiation, and metastasis. STK11 plays a central role in restricting HSC entry into cell cycle and in broadly maintaining energy homeostasis in hematopoietic cells through a novel metabolic checkpoint (1). STK11 serves as an essential regulator of HSCs and hematopoiesis, and more generally, points to the critical importance of coupling energy metabolism and stem cell homeostasis (2). SKT11 Protein is ideal for investigators involved in Signaling Proteins, Cellular Proteins, Apoptosis/Autophagy, Cancer, Cellular Stress, Metabolic Disorder, and Ser/Thr Kinases research.

STK16 is serine/threonine kinase 16 which constitute the catalytic subunit of a multisubunit kinase. STK16 is ubiquitously expressed at very low levels and expression of an STK16 fusion protein showed that STK16 is localized with Golgi and Golgi-derived vesicles. The overexpression of STK16 leads to disorganization of the Golgi apparatus into vesicular structures and STK16 is highly involved in the secretory pathway (1). STK16 is involved in the transforming growth factor (TGF)-beta signalling pathway (2). STK16 Protein is ideal for investigators involved in Signaling Proteins, Cellular Proteins, Cardiovascular Disease, ERK/MAPK Pathway, Neurobiology, PKA/PKC Pathway, and Ser/Thr Kinases research.

STK31 is a serine/threonine protein kinase that contains a tudor domain found in RNA-interacting proteins, and a coiled-coil domain. Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. The STK31 gene is conserved across many species and was originally identified as a gene expressed in mouse spermatogonia but not in somatic tissues (1). STK31 has been shown to be specifically expressed in the human testis. STK31 Protein is ideal for investigators involved in Signaling Proteins, Cellular Proteins, Cardiovascular Disease, ERK/MAPK Pathway, Neurobiology, PKA/PKC Pathway, and Ser/Thr Kinases research.

STK35 is serine/threonine kinase 35 which is a kinase that is predominantly found in the nucleus and interacts with PDLIM1/CLP-36 in the cytoplasm and localize to actin stress fibers. STK35 protein is a regulator of actin stress fibers in nonmuscle cells. STK35 specifically targets STK1 to actin stress fibers and that it may represent a regulator of the actomyosin cytoskeleton in nonmuscle cells (1). STK35 Protein is ideal for investigators involved in Signaling Proteins, Cellular Proteins, Cardiovascular Disease, ERK/MAPK Pathway, Neurobiology, PKA/PKC Pathway, and Ser/Thr Kinases research.

CHIP (STUB1) or STIP1 homology and U-box containing protein 1 (also known as E3 ubiquitin protein ligase) is an ubiquitin ligase/cochaperone that participates in protein quality control by targeting a broad range of chaperone protein substrates for degradation (1). CHIP acts as a molecular switch for the degradation of misfolded proteins via the proteasome and lysosome pathways (2). CHIP controls the cellular level of BER enzymes and, correspondingly, the efficiency and capacity of BER. CHIP E3 ubiquitin ligases act sequentially in ER membrane and cytosol to monitor the folding status of CFTR and delF508.CHIP possesses intrinsic E3 ubiquitin ligase activity and promotes ubiquitylation. STUB1 Protein is ideal for investigators involved in Signaling Proteins, Ubiquitin Proteins, Cell Cycle, Cellular Stress, Cytoplasmic Tyrosine Kinases, and Metabolic Disorder research.

STYK1 is belongs to serine/threonine/tyrosine kinase 1 family which play important roles in diverse cellular and developmental processes, such as cell proliferation, differentiation, and survival (1). STYK1 concomitantly activate both MAP kinase and PI3K pathways in stably transfected mouse pre-B cells and STYK1 expression is elevated in 92.3% cancerous tissues in comparison with normal tissues (2). STYK1 Protein is ideal for investigators involved in Signaling Proteins, Cellular Proteins, Cancer, Cell Cycle, Cytoplasmic Tyrosine Kinases, and Invasion/Metastasis research.

SUMO1 (also known as UBL1) is a member of the SUMO (small ubiquitin-like modifier) protein family which functions in a manner similar to ubiquitin. SUMO1 is bound to target proteins as part of a post-translational modification system and it is involved in a variety of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability (1). SUMO1 may be involved in the repair of TOP1-mediated DNA damage (2). The sumoylation pathway plays a significant role in mammalian DNA damage response. SUMO1 Protein is ideal for investigators involved in Signaling Proteins, Ubiquitin Proteins, Apoptosis/Autophagy, Cell Cycle, and NfkB Pathway research.

SUMO2 is a member of the SUMO (small ubiquitin-like modifier) protein family which functions in a manner similar to ubiquitin. SUMO2 is bound to target proteins as part of a post-translational modification system and modifies numerous cellular proteins and affect their metabolism and function. SUMO2 is also involved in a variety of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability (1). SUMO2 is predominantly detected on nuclear bodies (2). SUMO2 Protein is ideal for investigators involved in Signaling Proteins, Ubiquitin Proteins, Apoptosis/Autophagy, Cell Cycle, and NfkB Pathway research.

TAF1 is a DNA-binding protein complex required for RNA polymerase II-mediated transcription of many, if not all, protein-encoding genes in eukaryotic cells. TAF1 plays a key role in the initiation process, since it binds to the TATA element to form a complex that nucleates the assembly of the other components into a preinitiation complex and that may be stable through multiple rounds of transcription. TAF1 may be targeted to specific chromatin-bound promoters and may play a key role in chromatin recognition (1). TAF1 also serves to link the control of transcription to the cell cycle (2). TAF1 Protein is ideal for investigators involved in Signaling Proteins, Cellular Proteins, Cell Cycle, and Invasion/Metastasis research.