Other Proteins

Artemin is a novel member of the glial cell line-derived neurotrophic factor (GNDF) ligand family. Current evidence suggests that Artemin signals through the receptor complex, GFRα3-RET, to influence neuron survival in vitro and in vivo. Recombinant human Artemin is a non-glycosylated, disulfide-linked homodimer, containing two 113 amino acid chains, with a total molecular weight of 24.2 kDa.

Human B cell Activating Factor (BAFF), is a Type II member of the TNF superfamily. Although it is typically a transmembrane protein expressed on T cells, macrophages and dendritic cells, it can also be cleaved in the extracellular region to produce a soluble form detectable in the serum. BAFF is thought to be important for the survival and maturation of peripheral B cells. BAFF initiates signaling through three receptors with human BAFF having activity on mouse splenocytes. Recombinant human BAFF is a non-glycosylated protein containing a N terminal His tag, a thrombin cut site and 153 amino acids of the TNF-like domain. This protein has a total molecular weight of 18.5 kDa.

B cell Attracting Chemokine-1 (BCA-1), also known as CXCL13, is expressed at high levels in lymphoid tissues such as the spleen, lymph nodes and Peyer’s patches. It has been shown to activate signaling through the receptor BLR1 (Burkitt’s lymphoma receptor 1) to chemoattract B cells. Recombinant human BCA-1 is a non-glycosylated protein, containing 87 amino acids, with a molecular weight of 10.3 kDa.

B cell Attracting Chemokine-1 (BCA-1), also known as CXCL13, is expressed at high levels in lymphoid tissues such as the spleen, lymph nodes and Peyer’s patches. It has been shown to activate signaling through the receptor BLR1 (Burkitt’s lymphoma receptor 1) to chemoattract B cells. Recombinant human BCA-1 is a non-glycosylated protein, containing 87 amino acids, with a molecular weight of 10.3 kDa.

B cell Attracting Chemokine-1 (BCA-1), also known as CXCL13, is expressed at high levels in lymphoid tissues such as the spleen, lymph nodes and Peyer’s patches. It has been shown to activate signaling through the receptor BLR1 (Burkitt’s lymphoma receptor 1) to chemoattract B cells. Recombinant human BCA-1 is a non-glycosylated protein, containing 87 amino acids, with a molecular weight of 10.3 kDa.

CD40 Ligand (CD40-L), or CD154, is a membrane glycoprotein and differentiation antigen expressed on the surface of T cells. The CD40 Ligand stimulates B cell proliferation and secretion of all immunoglobulin isotypes in the presence of cytokines. CD40 Ligand has been shown to induce cytokine production and tumoricidal activity in peripheral blood monocytes. It also co-stimulates proliferation of activated T cells and this is accompanied by the production of IFN-gamma, TNF-α, and IL-2. Recombinant human CD40 Ligand is a non-glycosylated protein, containing 149 amino acids, with a molecular weight of 16.3 kDa.

CD40 Ligand (CD40-L), or CD154, is a membrane glycoprotein and differentiation antigen expressed on the surface of T cells. The CD40 Ligand stimulates B cell proliferation and secretion of all immunoglobulin isotypes in the presence of cytokines. CD40 Ligand has been shown to induce cytokine production and tumoricidal activity in peripheral blood monocytes. It also co-stimulates proliferation of activated T cells and this is accompanied by the production of IFN-gamma, TNF-α, and IL-2. Recombinant human CD40 Ligand is a non-glycosylated protein, containing 149 amino acids, with a molecular weight of 16.3 kDa.

Chemerin is a chemoattractant expressed in white adipose, liver and lung tissues. Chemerin is a ligand for the G-protein coupled receptor known as ChemR23 (or chemokine-like receptor-1), which is expressed mainly on dendritic cells, macrophages and some adipocytes. Recombinant human Chemerin is a non-glycosylated protein, containing 138 amino acids, with a total molecular weight of 16 kDa.

Chemerin is a chemoattractant expressed in white adipose, liver and lung tissues. Chemerin is a ligand for the G-protein coupled receptor known as ChemR23 (or chemokine-like receptor-1), which is expressed mainly on dendritic cells, macrophages and some adipocytes. Recombinant human Chemerin is a non-glycosylated protein, containing 138 amino acids, with a total molecular weight of 16 kDa.