Other Proteins

LMTK3, or Lemur tyrosine kinase 3, belongs to the LMR subfamily of tyr protein kinases. LMTK3 decreases the activity of protein kinase C (PKC) and also leads to phosphorylation of AKT (Ser473), thereby increasing binding of forkhead box O3 (FOXO3) to the ESR1 promoter. LMTK3 phosphorylates ERα, protecting it from proteasomal degradation in vitro. Knockdown of LMTK3 leads to a reduction of tumor volume in an orthotopic mouse model and abrogates proliferation of ERα+ but not ERα- cells, indicative of its role in ERα activity. These findings reveal LMTK3 as a new therapeutic target for breast cancer (1). LMTK3 Protein is ideal for investigators involved in Signaling Proteins, Cellular Proteins, Cancer, and Ser/Thr Kinases research.

LMTK3, or Lemur tyrosine kinase 3, belongs to the LMR subfamily of tyr protein kinases. LMTK3 decreases the activity of protein kinase C (PKC) and also leads to phosphorylation of AKT (Ser473), thereby increasing binding of forkhead box O3 (FOXO3) to the ESR1 promoter. LMTK3 phosphorylates ERα, protecting it from proteasomal degradation in vitro. Knockdown of LMTK3 leads to a reduction of tumor volume in an orthotopic mouse model and abrogates proliferation of ERα+ but not ERα- cells, indicative of its role in ERα activity. These findings reveal LMTK3 as a new therapeutic target for breast cancer (1). LMTK3 Protein is ideal for investigators involved in Signaling Proteins, Cellular Proteins, Cancer, and Ser/Thr Kinases research.

Exodus-2, also known as CCL21 and 6Ckine, is a novel chemokine produced at high levels in human lymph node tissue and the spleen. 6Ckine signals through the CCR7 receptor to recruit thymocytes and activated T cells in vitro, but is not known to be chemotactic for monocytes. Human and mouse Exodus-2 share > 85% amino acid identity. Recombinant mouse Exodus-2 is a non-glycosylated protein, containing 110 amino acids, with a molecular weight of 12 kDa.

Exodus-2, also known as CCL21 and 6Ckine, is a novel chemokine produced at high levels in human lymph node tissue and the spleen. 6Ckine signals through the CCR7 receptor to recruit thymocytes and activated T cells in vitro, but is not known to be chemotactic for monocytes. Human and mouse Exodus-2 share > 85% amino acid identity. Recombinant mouse Exodus-2 is a non-glycosylated protein, containing 110 amino acids, with a molecular weight of 12 kDa.

Exodus-2, also known as CCL21 and 6Ckine, is a novel chemokine produced at high levels in human lymph node tissue and the spleen. 6Ckine signals through the CCR7 receptor to recruit thymocytes and activated T cells in vitro, but is not known to be chemotactic for monocytes. Human and mouse Exodus-2 share > 85% amino acid identity. Recombinant mouse Exodus-2 is a non-glycosylated protein, containing 110 amino acids, with a molecular weight of 12 kDa.

Fibroblast Growth Factor-9 (FGF-9) is a steroid-regulated mitogen and survival factor for nerve and mesenchymal cells. FGF-9 is an autocrine/paracrine growth factor considered to be important for the growth and survival of motorneurons and prostate tissue. Recombinant mouse FGF-9 is non-glycosylated protein, containing 205 amino acids, with a molecular weight of 23.3 kDa.

Fibroblast Growth Factor-9 (FGF-9) is a steroid-regulated mitogen and survival factor for nerve and mesenchymal cells. FGF-9 is an autocrine/paracrine growth factor considered to be important for the growth and survival of motorneurons and prostate tissue. Recombinant mouse FGF-9 is non-glycosylated protein, containing 205 amino acids, with a molecular weight of 23.3 kDa.

Fibroblast Growth Factors, FGFs, are a 22 member family of proteins known to be involved in angiogenesis, wound healing and embryonic development. As a family, they bind to heparin and signal through four receptor tyrosine kinases called, FGFR1, 2, 3 and 4. Although the mechanism remains unclear, FGF-basic, or FGF-1, is a critical component in keeping human embryonic stem cells undifferentiated in cell culture systems. Recombinant mouse FGF basic is a non-glycosylated protein, containing 145 amino acids, with a molecular weight of 16.3 kDa.

Fibroblast Growth Factors, FGFs, are a 22 member family of proteins known to be involved in angiogenesis, wound healing and embryonic development. As a family, they bind to heparin and signal through four receptor tyrosine kinases called, FGFR1, 2, 3 and 4. Although the mechanism remains unclear, FGF-basic, or FGF-1, is a critical component in keeping human embryonic stem cells undifferentiated in cell culture systems. Recombinant mouse FGF basic is a non-glycosylated protein, containing 145 amino acids, with a molecular weight of 16.3 kDa.