Other Proteins

Recombinant Human sIL-15 Receptor alpha Fc (Legacy Tebubio ref. 167200-15RA). IL‐15 signaling is an important factor in proliferating, activating, and immunomodulating primarily T cells. IL‐15R alpha is an IL‐15 specific, single pass membrane receptor which complexes with IL‐2R beta and IL‐2R gamma to form a high affinity IL‐15 receptor. Additionally, the IL‐15/IL‐15R complex is capable of binding to IL‐2 beta/gamma receptors on other cells, therefore enabling IL‐15 to indirectly activate cells expressing IL‐2 beta/gamma receptors. A soluble form of IL‐15 receptor alpha is naturally produced by proteolytic cleavage of the membrane‐bound precursor. This naturally occurring soluble form can act as a modulator of IL‐15 signaling through the inhibition of IL‐15 receptor binding. Recombinant Human sIL‐15 Receptor alpha Fc has a calculated molecular weight of 44.4 kDa protein and contains 408 amino acid residues, which consists of the extracellular domain of IL‐15R alpha fused to the Fc port

Recombinant Human sIL-15 Receptor alpha Fc (Legacy Tebubio ref. 167200-15RA). IL‐15 signaling is an important factor in proliferating, activating, and immunomodulating primarily T cells. IL‐15R alpha is an IL‐15 specific, single pass membrane receptor which complexes with IL‐2R beta and IL‐2R gamma to form a high affinity IL‐15 receptor. Additionally, the IL‐15/IL‐15R complex is capable of binding to IL‐2 beta/gamma receptors on other cells, therefore enabling IL‐15 to indirectly activate cells expressing IL‐2 beta/gamma receptors. A soluble form of IL‐15 receptor alpha is naturally produced by proteolytic cleavage of the membrane‐bound precursor. This naturally occurring soluble form can act as a modulator of IL‐15 signaling through the inhibition of IL‐15 receptor binding. Recombinant Human sIL‐15 Receptor alpha Fc has a calculated molecular weight of 44.4 kDa protein and contains 408 amino acid residues, which consists of the extracellular domain of IL‐15R alpha fused to the Fc port

Recombinant Human IL-23 (Legacy Tebubio ref. 167200-23). IL-23 is a proinflammatory, heterodimeric protein composed of two subunits: a unique p19 subunit, and a p40 subunit that is shared with IL-12. IL-23 is secreted by activated dendritic cells and macrophages, and signals though a receptor comprised of IL-23R complexed with IL-12Rbeta1. IL-23 has been shown to enhance proliferation of memory T cells. It also stimulates the production of IFN-gamma in NK cells, induces IL-17 production, and drives Th17-mediated responses. Recombinant Human IL-23 is a 53.5 kDa, heterodimeric protein consisting of the two subunits, p19 (170 amino acids) and p40 (306 amino acids).

Recombinant Human IL-23 (Legacy Tebubio ref. 167200-23). IL-23 is a proinflammatory, heterodimeric protein composed of two subunits: a unique p19 subunit, and a p40 subunit that is shared with IL-12. IL-23 is secreted by activated dendritic cells and macrophages, and signals though a receptor comprised of IL-23R complexed with IL-12Rbeta1. IL-23 has been shown to enhance proliferation of memory T cells. It also stimulates the production of IFN-gamma in NK cells, induces IL-17 production, and drives Th17-mediated responses. Recombinant Human IL-23 is a 53.5 kDa, heterodimeric protein consisting of the two subunits, p19 (170 amino acids) and p40 (306 amino acids).

Recombinant Human IL-36beta (IL-1F8) (Legacy Tebubio ref. 167200-36B). The IL-1 family is comprised of 11 structurally related ligands, including recently re-named IL-36alpha (IL-1F6), beta (IL-1F8) and gamma (IL-1F9). IL-36beta is highly expressed in psoriatic plaques, and at lower levels in various other tissues. IL-36beta signals through the IL-1Rrp2 (IL-1R6) receptor, which is primarily expressed on certain dendritic cells. The interaction of the IL-1Rrp2 receptor with IL-36 ligands induces dendritic cell maturation and activation. IL-36beta also functions as an agonist of NF-kappaB, and stimulates the production of pro-inflammatory proteins, including IL-6, IL-8, BD-2, and BD-3. Recombinant Human IL-36beta is a 17.3 kDa protein containing 154 amino acid residues.

Recombinant Human IL-36beta (IL-1F8) (Legacy Tebubio ref. 167200-36B). The IL-1 family is comprised of 11 structurally related ligands, including recently re-named IL-36alpha (IL-1F6), beta (IL-1F8) and gamma (IL-1F9). IL-36beta is highly expressed in psoriatic plaques, and at lower levels in various other tissues. IL-36beta signals through the IL-1Rrp2 (IL-1R6) receptor, which is primarily expressed on certain dendritic cells. The interaction of the IL-1Rrp2 receptor with IL-36 ligands induces dendritic cell maturation and activation. IL-36beta also functions as an agonist of NF-kappaB, and stimulates the production of pro-inflammatory proteins, including IL-6, IL-8, BD-2, and BD-3. Recombinant Human IL-36beta is a 17.3 kDa protein containing 154 amino acid residues.

Recombinant Human IL-36gamma (IL-1F9) (Legacy Tebubio ref. 167200-36G). The IL-1 family is comprised of 11 structurally related ligands, including recently re-named IL-36 alpha (IL-1F6), beta (IL-1F8) and gamma (IL-1F9). IL-36gamma is highly expressed in psoriatic plaques and in tissues containing epithelial cells. IL-36gamma signals through the IL-1Rrp2 (IL-1R6) receptor, which is primarily expressed on certain dendritic cells. The interaction of the IL-1Rrp2 receptor with IL-36 ligands induces dendritic cell maturation and activation. IL-36gamma also functions as an agonist of NF-kappaB, and can stimulate the inflammatory response in bronchial epithelial cells. Recombinant Human IL-36gamma is a 17.0 kDa protein containing 152 amino acid residues.

Recombinant Human IL-36gamma (IL-1F9) (Legacy Tebubio ref. 167200-36G). The IL-1 family is comprised of 11 structurally related ligands, including recently re-named IL-36 alpha (IL-1F6), beta (IL-1F8) and gamma (IL-1F9). IL-36gamma is highly expressed in psoriatic plaques and in tissues containing epithelial cells. IL-36gamma signals through the IL-1Rrp2 (IL-1R6) receptor, which is primarily expressed on certain dendritic cells. The interaction of the IL-1Rrp2 receptor with IL-36 ligands induces dendritic cell maturation and activation. IL-36gamma also functions as an agonist of NF-kappaB, and can stimulate the inflammatory response in bronchial epithelial cells. Recombinant Human IL-36gamma is a 17.0 kDa protein containing 152 amino acid residues.

Recombinant Human IL-36RA (Legacy Tebubio ref. 167200-36RA). The IL-1 family is comprised of 11 structurally related ligands, including the recently re-named IL-36RA (IL-1F5), IL-36alpha (IL-1F6), IL-36beta (IL-1F8), and IL-36gamma (IL-1F9). The interaction of IL-36 ligands with the IL-1Rrp2 receptor (IL-1R6) can induce various activities, including dendritic cell maturation and activation. IL-36RA can antagonize the NF-kappaB signaling induced by either IL-36alpha, beta or gamma by binding to the IL-1Rrp2 receptor in a manner that prevents the initiation of functional signaling. Recombinant Human IL-36RA is an E.coli-derived 17 kDa protein containing 154 amino acid residues.