Since lysosomal and mitochondrial dysfunction is deeply involved in the onset and progression of neurodegenerative diseases and other disorders, detailed analysis of lysosomes and mitochondria has attracted much attention in elucidating pathological conditions and developing therapeutic agents.
Discover four new dyes to study the lysosome:
HeLa cells
Baf.A1: Bafilomycin A1 (lysosomal acidification inhibitor)
Product Name | pHLys Green | pHLys Red | LysoPrime Green | LysoPrime Deep Red |
---|---|---|---|---|
Purpose | pH | pH | Mass | Mass |
Fluorescent property | Ex= 488 nm
Em= 490-550 nm | Ex= 561 nm Em= 560-650 nm | Ex= 488 nm Em= 500-600 nm | Ex= 633 nm Em= 640-700 nm |
Lysosome pH sensitivity | ✓ | ✓ | Resistant to pH change | Resistant to pH change |
Lysosome specificity | ✓ | ✓ | ✓ | ✓ |
Lysosome retention | ✓ | ✓ | ✓ | ✓ |
Supported devices | Microscope Plate Reader FCM | Microscope Plate Reader FCM (Need G/Y Laser: G: 532 nm, Y: 561 nm) | Microscope Plate Reader FCM | Microscope Plate Reader FCM |
pH: detection of accurate pH changes.
Mass : detection of volume changes.
Ref: L261-10 - Size: 1 tube (10 µL)
Ref: L264-10 - Size: 1 tube
Ref: L265-10 - Size: 1 tube
Ref: L266-10 - Size: 1 set
Ref: L268-10 - Size: 1 set
Refs: MT14-10, MT14-12 - Sizes: 100 nmol, 100x3 nmol
Co-staining with mtSOX and Lysosomal dyes revealed that CCCP, unlike Antimycin, triggers concurrent lysosomal neutralization and mitochondrial ROS induction.
Explore our wide range of lysosomal and mitochondrial staining and pH detection dyes, and find the kit or reagent that suits your experimental requirements.
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