Ferroptosis is a form of programmed cell death that is caused by iron ion-dependent accumulation of lipid peroxides. Ferroptosis has been shown to follow a different cell death pathway to apoptosis. This cellular mechanism is therefore attracting attention as a new target for cancer therapy, neurodegenerative diseases and hepatitis (NASH).
Are you looking for potential therapeutic targets for senescence-associated diseases? Discover our offer divided into two product categories: the lipid peroxide and iron detection reagents & the oxidative stress- and metabolism-related reagents and kits.
This complete solution from our partner Dojindo will help you to identify iron metabolism targets.
Product Name | Liperfluo | MitoPeDPP | Mito-FerroGreen | FerroOrange |
|---|---|---|---|---|
Item# | L248 | M466 | M489 | F374 |
Target | Lipid Peroxidation | Lipid Peroxidation | Ferrous Ion (Fe2+) | Ferrous Ions (Fe2+) |
Localisation | Intracellular | Mitochondria | Mitochondria | Mitochondria |
Detection | Fluorescence (524 nm/535 nm) | Fluorescence (452 nm/470nm) | Fluorescence (505nm/580nm) | Fluorescence (543nm/580nm) |
Instrument | Fluorescence Microscope, FCM | Fluorescence Microscope, FCM | Fluorescence Microscope, Microplate Reader | Fluorescence Microscope |
Sample | Live Cell | Live Cell | Live Cell | Live Cell |
FerroOrange (F374) – Live Cell Imaging
Ex/Em = 561 nm/570-620 nm, Scale bars 20 μm
A: Control
B: Ammonium iron (II) sulfate and 2,2′-Bipyridyl (Bpy) treated
C: Ammonium iron (II) sulfate treated
The fluorescence intensity of FerroOrange was increased in HeLa cells treated with Ammonium iron (II) sulfate compared with the findings in untreated cells; conversely, its fluorescence intensity was decreased in cells treated with Bpy.
Product Name | ROS Assay Kit | GSSG/GSH Quantification Kit | Glutamine Assay Kit-WST | Glutamate Assay Kit-XDT |
|---|---|---|---|---|
Item# | R252 | G257 | G268 | G269 |
Target | ROS (Reactive oxygen species) | Glutathione (oxidized/reduced) | Glutamine | Glutamate |
Localisation | Intracellular | Intracellular | Intracellular/Extracellular | Intracellular/Extracellular |
Detection | Fluorescence (505 nm/525 nm) | Colorimetric: 412 nm | Colorimetric: 450 nm | Colorimetric: 450 nm |
Instrument | Fluorescence Microscope, FCM, Microplate Reader | Microplate Reader | Microplate Reader | Microplate Reader |
Sample | Live Cell | Cell, Tissue, Blood Plasma, Red Blood Cell | Cell, Cell Culture | Cell, Cell Culture |
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