Enhance Your Therapeutic mRNA Research Projects with Modified NTPs

By Tebubio, June 2024

An Insight from the Tebubio Team

Discover how modified nucleoside triphosphates (NTPs) are revolutionising mRNA vaccine technology by enhancing translation. Get the opportunity to access the best tools for advancing your mRNA therapeutic research thanks to Tebubio.

"Since the N1-methyl-pseudo-UTP (N1mΨ) modification gained popularity from its use in the Pfizer/BioNTech SARS-CoV-2 vaccine, I have found it to be the best modification for protein expression."

Dimitri Szymczak, PhD

Scientific Support Team at Tebubio

How Modified NTPs are Revolutionising mRNA Vaccine Technology

In recent years, the spotlight on mRNA (messenger RNA) technology has intensified, largely due to its pivotal role in developing COVID-19 vaccines.

However, this groundbreaking technology, is just the tip of the iceberg. The development of modified NTPs used in the creation of vaccines (cancer, covid-19, others…) has propelled mRNA research into new frontiers, enhancing stability, efficiency, and effectiveness.

Using NTPs as Building Blocks to Enhance mRNA Efficiency

Imagine the NTPs as being the building blocks of a house, the house being your mRNA. These NTPs are essential components of your mRNA.

To design your mRNA, it is crucial to have the key building blocks that allow you to achieve an optimised, functional, and stable structure. The best way to design an efficient mRNA structure is to use modified NTPs.

TriLink a pioneer with 25 years of expertise in advancing mRNA therapeutics, and a long-standing partner of Tebubio, has recently introduced 3 new sets of modified NTPs.

Access easily the nucleotides of your interest, in your needed size¹

NTPs: a Proven Solution for the Advancement of mRNA Therapeutics

Now that it’s established that using modified NTPs leads to efficient mRNA synthesis, you’re probably wondering why it’s necessary to use modified NTPs over traditional ones? It’s quite simple! Let’s explore this together.

It has been demonstrated² that uridine, a component of mRNA, has an immunogenic effect within cells and can lead to its elimination.

But, to suppress this immunogenicity and optimise the performance of vaccines and therapeutics, the use of modified uridine has proven effective by:

Enhancing mRNA stability
Boosting translation efficiency

Do you find this remarkable as well?

Then you’ll want to discover these 3 sets of NTPs (A, C, G & modified U) from our valued partner TriLink, each containing a thoughtfully chosen uridine modification to improve therapeutic outcomes:

Refer to the following graphic to knowingly choose the best uridine modification according to your cells model.