Please note this product may be subject to fees, we invite you to contact your local office. Human IL-2 reporter construct is stably integrated into the genome of Jurkat T-cells. The firefly luciferase gene is controlled by a human IL-2 promoter.

Please note this product may be subject to fees, we invite you to contact your local office. Recombinant HEK293 cell expressing firefly luciferase gene under the control of NF-κB response elements with constitutive expression of human OX40 (Tumor Necrosis Factor Receptor Superfamily Member 4, TNFRSF4, and CD134, GenBank Accession No. NM_003327)

Please note this product may be subject to fees, we invite you to contact your local office. Recombinant CHO-K1 cell constitutively expressing full-length human CD137L (NP_003802.1). Surface expression is confirmed by flow cytometry.

Please note this product may be subject to fees, we invite you to contact your local office. Stable Recombinant HEK293 cell line expressing tetracycline-inducible human indoleamine 2,3-dioxygenase (IDO1) Genbank accession number NM_002164.

Please note this product may be subject to fees, we invite you to contact your local office. Recombinant HEK293 cell line expressing tetracycline-inducible human indoleamine 2,3-dioxygenase (IDO2), Genbank accession number NM_194294.

Please note this product may be subject to fees, we invite you to contact your local office. Stable recombinant HEK293 cell line expressing human tryptophan 2,3 dioxygenase (TDO2, TDO, TPH2, TRPO), Genbank accession number NM_005651.

Please note this product may be subject to fees, we invite you to contact your local office. Recombinant Jurkat T cell expressing firefly luciferase gene under the control of NFAT response elements with constitutive expression of human PD-1 (Programmed Cell Death 1, PDCD1, SLEB2, CD279, GenBank Accession #NM_005018).

Please note this product may be subject to fees, we invite you to contact your local office. Recombinant CHO-K1 cells constitutively expressing human PD-L1 (Programmed Cell Death 1 Ligand 1, CD274, B7 homolog 1 (B7- H1), GenBank accession # NM_014143) an engineered T cell receptor (TCR) activator.

Please note this product may be subject to fees, we invite you to contact your local office. Recombinant HEK293 cell line expressing full length human CD155, also known as poliovirus receptor (PVR) or nectin-like molecule-5 (NECL-5). Expression is confirmed by Western Blot.

Please note this product may be subject to fees, we invite you to contact your local office. Recombinant Jurkat cell line constitutively expressing a full length human TIGIT (T cell Immunoreceptor with Immunoglobulin and ITIM domain; VSTM3), and a firefly luciferase gene under the control of nuclear factor of activator T cells (NFAT) response element. Both TIGIT and NFAT constructs have been stably integrated into Jurkat cells. TIGIT expression has been confirmed by Western Blot, and TIGIT-specific NFAT response has been validated using a TIGIT ligand, CD155 (PVR).

Please note this product may be subject to fees, we invite you to contact your local office. Recombinant Jurkat T cell expressing firefly luciferase gene under the control of NFAT response elements with constitutive expression of human FcγRIIIa, low affinity (F158) variant and Fcγ chain.

Please note this product may be subject to fees, we invite you to contact your local office. Recombinant Jurkat T cell expressing firefly luciferase gene under the control of NFAT response elements with constitutive expression of human FcγRIIIa, high affinity (V158) variant and Fcγ chain.

Please note this product may be subject to fees, we invite you to contact your local office. Recombinant CHO-K1 cells constitutively expressing human PD-L1 (Programmed Cell Death 1 Ligand 1, CD274, B7 homolog 1 (B7- H1), GenBank accession #NM_014143).

Please note this product may be subject to fees, we invite you to contact your local office. PAI-1 Reporter (Luc)-Mv1 Lu cell line is designed for monitoring transforming growth factor β (TGF-β)-induced plasminogen activator inhibitor-1 (PAI-1) expression. Transforming growth factor-β (TGF-β) is a potent regulator of cellular differentiation, proliferation, migration, and protein expression. PAI-1 Reporter (Luc) -Mv1 Lu cell line contains a firefly luciferase gene under the control of PAI-1 responsive elements stably integrated into Mv1 Lu (NBL-7) cells, showing TGF-β pathway response. This cell line is validated for the TGF-β response to the induction of PAI-1 gene expression through luciferase activity.

Please note this product may be subject to fees, we invite you to contact your local office. This cell line expresses a surface human GITR (glucocorticoid-induced TNFR family related gene; TNFRSF18; CD357) and an NF-κB luciferase reporter construct that are stably integrated into the genome of Jurkat T-cells. The firefly luciferase gene is controlled by 4 copies of NF-κB response element located upstream of the TATA promoter. Following activation by stimulants, endogenous NF-κB transcription factors bind to the DNA response elements to induce transcription of the luciferase gene. The cells have been validated using purified human GITRL and anti-GITR neutralizing antibody.

Please note this product may be subject to fees, we invite you to contact your local office. Recombinant CHO-K1 cell constitutively expressing full length human GITRL (NP_005083.2). Surface expression is confirmed by flow cytometry.

Please note this product may be subject to fees, we invite you to contact your local office. Recombinant CHO-K1 cells constitutively expressing human CD155 (Poliovirus receptor, Nectin-like protein 5, GenBank accession #NM_006505) and an engineered T cell receptor (TCR) activator.

Please note this product may be subject to fees, we invite you to contact your local office. Recombinant Raji cell expressing an engineered T cell receptor (TCR) activator.

Please note this product may be subject to fees, we invite you to contact your local office. CHO-K1 cell line expressing full length human CD27 (TNFRSF7). Expression is confirmed by real time qPCR and Western blot. Screening for antibodies recognizing CD27 and screening antibodies for binding affinities. Since<br />CHO-K1 cells do not express endogenous CD27, this cell line serves as an excellent model for<br />studying changes in CD27-mediated signaling pathways, such as NF-?B, MAPK and<br />SAPK/JNK.

Please note this product may be subject to fees, we invite you to contact your local office. NF-κB luciferase reporter construct is stably integrated into the genome of A549 cells. The firefly luciferase gene is controlled by 4 copies of NF-κB response element located upstream of the TATA promoter. Following activation by stimulants, endogenous NF-κB transcription factors bind to the DNA response elements to induce transcription of the luciferase gene.

Please note this product may be subject to fees, we invite you to contact your local office. Recombinant HEK293 cell line expressing full length human CD40 (Tumor necrosis factor receptor superfamily member 5; TNFRSF5). Expression is confirmed by flow cytometry and Western Blot. This NF-κB luciferase reporter construct is stably integrated into the genome. The firefly luciferase gene is controlled by 4 copies of NF-κB response element located upstream of the TATA promoter. Following activation by human CD40 ligand, NF-κB transcription factor binds to the DNA response elements to induce transcription of the luciferase gene.

Please note this product may be subject to fees, we invite you to contact your local office. Human Foxp3 luciferase reporter construct is stably integrated into the genome of Jurkat T- cells. The firefly luciferase gene is controlled by a human Foxp3 promoter and an enhancer-like conserved noncoding sequence upstream of the Foxp3 promoter.

Please note this product may be subject to fees, we invite you to contact your local office. NF-κB luciferase reporter construct is stably integrated into the genome of Jurkat T- cells. The firefly luciferase gene is controlled by 4 copies of NF-kB response element located upstream of the TATA promoter. Following activation by stimulants, endogenous NF-κB transcription factors bind to the DNA response elements to induce transcription of the luciferase gene.

Please note this product may be subject to fees, we invite you to contact your local office. Recombinant HEK293 stably expressing human PD-1 (Programmed Cell Death 1, PDCD1, SLEB2, CD279, GenBank Accession #NM_005018).

Please note this product may be subject to fees, we invite you to contact your local office. Recombinant HEK293 stably expressing human CTLA4 (Cytotoxic T-Lymphocyte Associated Protein; CD152), GenBank Accession #NM_005214.

Please note this product may be subject to fees, we invite you to contact your local office. Recombinant HEK293 stably expressing human OX40 (TNF receptor superfamily member 4, TNFRSF4, ACT35; CD134; IMD16; TXGP1L, GenBank Accession #NM_003327).

Please note this product may be subject to fees, we invite you to contact your local office. Recombinant HEK293 cell expressing firefly luciferase gene under the control of NFκB response elements with constitutive expression of human TLR8 (Toll-like receptor 8, also known as CD288, a member of the toll-like receptor (TLR) family (GenBank Accession No. NM_138636).

Please note this product may be subject to fees, we invite you to contact your local office. Recombinant HEK293 cell expressing firefly luciferase gene under the control of NF-κB response elements with constitutive expression of human TLR9 (Toll-like receptor 9, also been designated as CD289, a member of the toll-like receptor (TLR) family. GenBank Accession No. NM_017442)

Please note this product may be subject to fees, we invite you to contact your local office. Recombinant HEK293 cell constitutively expressing full length human SIRPα (#NM_080792). Surface expression is confirmed by flow cytometry.

Please note this product may be subject to fees, we invite you to contact your local office. Recombinant HEK293 cell constitutively expressing full length human CD137 (Genbank #NM_003811). Surface expression is confirmed by flow cytometry.

Please note this product may be subject to fees, we invite you to contact your local office. Recombinant HEK293 stably expressing human OX40 (TNF receptor superfamily member 4, TNFRSF4, ACT35; CD134; IMD16; TXGP1L, GenBank Accession #NM_003327).

Please note this product may be subject to fees, we invite you to contact your local office. Recombinant HEK293 cell constitutively expressing full length human SIRPα (#NM_080792). Surface expression is confirmed by flow cytometry.

Please note this product may be subject to fees, we invite you to contact your local office. Recombinant HEK293 cell constitutively expressing full length human CD137 (Genbank #NM_003811). Surface expression is confirmed by flow cytometry.

Please note this product may be subject to fees, we invite you to contact your local office. The PD-1/PD-L1 Inhibitor Screening Cell-Based Assay is a bioluminescent cell-based assay that can be used to screen and profile inhibitors of PD-1:PD-L1 or PD-1:PD-L2 interaction. The assay consists of two main components: • PD-1 Effector cells (PD-1/NFAT reporter-Jurkat cells): Reporter Jurkat T cells expressing firefly luciferase gene under the control of NFAT response elements and also constitutively expressing human PD-1. These cryopreserved cells are provided in a thaw-and-use format that does not require cell propagation. • Expression vectors for TCR activator, human PD-L1, and human PD-L2: Transfection-ready vectors are used to transfect cells to create the target cells that overexpress PD-L1 or PD-L2 and an engineered cell surface T cell receptor (TCR) activator.

Please note this product may be subject to fees, we invite you to contact your local office. The IDO1 Cellular Activity QuickDetectTM Supplements are designed to complement the hIDO1-HEK293 Recombinant Cell Line (BPS Cat. #60532) or other IDO1- expressing cell lines. This kit contains the cell culture medium supplements necessary for activation of IDO1 and for the analysis and detection of tryptophan 2,3 dioxygenase (IDO1)- catalyzed conversion of L-tryptophan (L-Trp) to Kynurenine (Kyn). The supplements and the detection reagents, when used as described, allow for indirect measurement of Kyn levels by analyzing absorption at 480 nm.

Please note this product may be subject to fees, we invite you to contact your local office. The IDO2 Cellular Activity QuickDetect™ Supplements are designed to complement the hIDO2-HEK293 Recombinant Cell Line (BPS Cat. #60532) or other IDO2- expressing cell lines. This kit contains the cell culture medium supplements necessary for activation of IDO2 and for the analysis and detection of indoleamine 2,3 dioxygenase (IDO2)- catalyzed conversion of L-tryptophan (L-Trp) to Kynurenine (Kyn). The supplements and the detection reagents, when used as described, allow for indirect measurement of Kyn levels by analyzing absorption at 480 nm.

Please note this product may be subject to fees, we invite you to contact your local office. Recombinant HEK293 cell line over-expressing full length human CD47 (NM_198793.2). Surface expression is confirmed by flow cytometry.

Please note this product may be subject to fees, we invite you to contact your local office. Recombinant HEK293 cell line expressing full length human CD40 (Tumor necrosis factor receptor superfamily member 5; TNFRSF5), Genbank Accession No. NP_001241.1. Expression is confirmed by real-time qPCR and Western blot.

Please note this product may be subject to fees, we invite you to contact your local office. Recombinant Jurkat T cell expressing a firefly luciferase gene under the control of NFAT response elements with constitutive expression of human FcγRIIa, Histidine variant.

Please note this product may be subject to fees, we invite you to contact your local office. Recombinant Jurkat T cell expressing firefly luciferase gene under the control of NFAT response elements with constitutive expression of human LAG-3 (lymphocyte-activation gene 3, CD223, GenBank Accession # NM_002286).

Please note this product may be subject to fees, we invite you to contact your local office. Recombinant human Nectin4-CHO K1 cell line stably expressing a full length human Nectin4/PVRL4 receptor (GenBank Accession: NM_030916.2). Surface expression of hNectin4 was confirmed by flow cytometry. Each stable clonal cell line was selected for different levels of hNectin4 expression (High, Medium, Low) to mimic different stages of cancer target cells with various Nectin4 expression levels.

Please note this product may be subject to fees, we invite you to contact your local office. Recombinant human Nectin4-CHO K1 cell line stably expressing a full length human Nectin4/PVRL4 receptor (GenBank Accession: NM_030916.2). Surface expression of hNectin4 was confirmed by flow cytometry. Each stable clonal cell line was selected for different levels of hNectin4 expression (High, Medium, Low) to mimic different stages of cancer target cells with various Nectin4 expression levels.

Please note this product may be subject to fees, we invite you to contact your local office. Recombinant human Nectin4-CHO K1 cell line stably expressing a full length human Nectin4/PVRL4 receptor (GenBank Accession: NM_030916.2). Surface expression of hNectin4 was confirmed by flow cytometry. Each stable clonal cell line was selected for different levels of hNectin4 expression (High, Medium, Low) to mimic different stages of cancer target cells with various Nectin4 expression levels.

Please note this product may be subject to fees, we invite you to contact your local office. Recombinant HEK-293 cells expressing firefly luciferase gene under the control of Nuclear factor-κB (NF-κB) with constitMedium 1Gutive expression of human RANK (Receptor activator of nuclear factor-κB; TNFRSF11A; ref. seq. NM_003839.2).

Please note this product may be subject to fees, we invite you to contact your local office. Recombinant CD5-CHO K1 cell line stably expressing a full-length human CD5 receptor (accession number: NM_014207.3). Surface expression of hCD5 was confirmed by flow cytometry. Each stable clonal cell line was selected for different levels of hCD5 expression (High, Medium and Low) to mimic different stages of cancer target cells with various CD5 expression levels.

Please note this product may be subject to fees, we invite you to contact your local office. Recombinant CD5-CHO K1 cell line stably expressing a full-length human CD5 receptor (accession number: NM_014207.3). Surface expression of hCD5 was confirmed by flow cytometry. Each stable clonal cell line was selected for different levels of hCD5 expression (High, Medium and Low) to mimic different stages of cancer target cells with various CD5 expression levels.

Please note this product may be subject to fees, we invite you to contact your local office. Recombinant CD5-CHO K1 cell line stably expressing a full-length human CD5 receptor (accession number: NM_014207.3). Surface expression of hCD5 was confirmed by flow cytometry. Each stable clonal cell line was selected for different levels of hCD5 expression (High, Medium and Low) to mimic different stages of cancer target cells with various CD5 expression levels.

Please note this product may be subject to fees, we invite you to contact your local office. Recombinant CHO-K1 cells constitutively expressing human B7-H7 (also known as HHLA2: HERV-H LTR-associating protein 2, GenBank accession #NM_007072) and an engineered T cell receptor (TCR) activator. B7-H7 mediates an immune-stimulatory signal via TMIGD2 (Transmembrane and immunoglobulin domain containing 2) in naÍve T cells while it delivers an immune-inhibitory signal through KIR3DL3 in activated T cells and Natural Killer (NK) cells.

Please note this product may be subject to fees, we invite you to contact your local office. Recombinant Jurkat cell line expressing firefly luciferase under the control of an NFAT response element, and with constitutive expression of human TMIGD2 (Transmembrane and immunoglobulin domain containing 2; CD28H; NM_144615). Expression of the firefly luciferase gene is driven by NFAT response elements located upstream of the minimal TATA promoter. Activation of the NFAT signaling pathway in these cells can be monitored by measuring luciferase activity. 

Please note this product may be subject to fees, we invite you to contact your local office. Recombinant HEK293 stably expressing human CTLA4 (Cytotoxic T-Lymphocyte Associated Protein; CD152), GenBank Accession #NM_005214.

Please note this product may be subject to fees, we invite you to contact your local office. Recombinant CD7 CHO-K1 cell lines expressing full-length human CD7 receptor (accession number: NM_006137.6). Surface expression of human CD7 was confirmed by flow cytometry. Each stable clonal cell line was selected for high or medium levels of CD7 expression to mimic different stages of cancer target cells with various CD7 expression levels.

Please note this product may be subject to fees, we invite you to contact your local office. Recombinant CD7 CHO-K1 cell lines expressing full-length human CD7 receptor (accession number: NM_006137.6). Surface expression of human CD7 was confirmed by flow cytometry. Each stable clonal cell line was selected for high or medium levels of CD7 expression to mimic different stages of cancer target cells with various CD7 expression levels.

Please note this product may be subject to fees, we invite you to contact your local office. Recombinant clonal CHO-K1 stable cell line constitutively expressing full length human CD2 protein.  The surface expression of CD2 in this cell line was validated by flow cytometry.

Please note this product may be subject to fees, we invite you to contact your local office. Recombinant CHO cell line stably expressing full length human CD43 gene (sialophorin, gpL115, leukosialin, SPN; ref. seq. NM_003123) under the control of the CMV promoter.

Please note this product may be subject to fees, we invite you to contact your local office. Recombinant clonal CHO stable cell line constitutively expressing full length human CD14 protein.  The surface expression of CD14 in this cell line was validated by flow cytometry.

Please note this product may be subject to fees, we invite you to contact your local office. Recombinant clonal CHO stable cell line constitutively expressing full length human CD34 protein. The surface expression of CD34 in this cell line was validated by flow cytometry.

Please note this product may be subject to fees, we invite you to contact your local office. Recombinant clonal CHO-K1 stable cell line constitutively expressing full-length human NCAM1 protein (Neural cell adhesion molecule 1, also known as CD56, single-pass type I membrane protein, isoform 1- Seq ID: NM_000615).  The NCAM1 (CD56) CHO cell line is provided as three different stable, clonal cell lines. Each cell line was selected for different levels of NCAM1 expression: low (L), medium (M) or high (H). Variable expression levels are advantageous for validating antibodies or compounds in binding assays.  A drug discovery program may find value in owning all three clones with differential expression of NCAM1. The surface expression of NCAM1 in each cell line was validated in parallel by flow cytometry. 

Please note this product may be subject to fees, we invite you to contact your local office. Recombinant clonal CHO-K1 stable cell line constitutively expressing full-length human NCAM1 protein (Neural cell adhesion molecule 1, also known as CD56, single-pass type I membrane protein, isoform 1- Seq ID: NM_000615).  The NCAM1 (CD56) CHO cell line is provided as three different stable, clonal cell lines. Each cell line was selected for different levels of NCAM1 expression: low (L), medium (M) or high (H). Variable expression levels are advantageous for validating antibodies or compounds in binding assays.  A drug discovery program may find value in owning all three clones with differential expression of NCAM1. The surface expression of NCAM1 in each cell line was validated in parallel by flow cytometry. 

Please note this product may be subject to fees, we invite you to contact your local office. Recombinant clonal CHO-K1 stable cell line constitutively expressing full-length human NCAM1 protein (Neural cell adhesion molecule 1, also known as CD56, single-pass type I membrane protein, isoform 1- Seq ID: NM_000615).  The NCAM1 (CD56) CHO cell line is provided as three different stable, clonal cell lines. Each cell line was selected for different levels of NCAM1 expression: low (L), medium (M) or high (H). Variable expression levels are advantageous for validating antibodies or compounds in binding assays.  A drug discovery program may find value in owning all three clones with differential expression of NCAM1. The surface expression of NCAM1 in each cell line was validated in parallel by flow cytometry. 

Please note this product may be subject to fees, we invite you to contact your local office. Recombinant Jurkat cells constitutively expressing the firefly (Photinus pyralis) luciferase reporter  gene under the control of a CMV promoter.

Please note this product may be subject to fees, we invite you to contact your local office. Recombinant HEK293 cells constitutively expressing full length human FcRL5 (Fc Receptor Like 5, also known as CD307, ref. seq. NM_031281).

Please note this product may be subject to fees, we invite you to contact your local office. Recombinant CHO-K1 cells constitutively expressing full length human FcRL5 (Fc Receptor Like 5, also known as CD307, ref. seq. NM_031281).

Please note this product may be subject to fees, we invite you to contact your local office. Recombinant stable MM.1S cell line constitutively expressing a firefly luciferase and enhanced GFP (eGFP) cassette  driven by a CMV promoter.

Please note this product may be subject to fees, we invite you to contact your local office. Recombinant RPMI 8226 cells constitutively expressing firefly (Photinus pyralis) luciferase (BPS Bioscience #79834) have also been engineered to constitutively express the full length human FcRL5 (Fc Receptor Like 5, also known as CD307, ref. seq. NM_031281).

Please note this product may be subject to fees, we invite you to contact your local office. Recombinant MC38 cells constitutively expressing the firefly (Photinus pyralis) luciferase gene under the control of a CMV promoter.

Please note this product may be subject to fees, we invite you to contact your local office. Recombinant Jurkat T-cells expressing an enhanced GFP (eGFP) gene under the control of NFAT response elements located upstream of the minimal TATA promoter. Activation of the NFAT signaling pathway can be monitored by examining eGFP expression.

Please note this product may be subject to fees, we invite you to contact your local office. This recombinant Jurkat cell line is a biologically relevant system to measure activation of the IL-15 cytokine receptor by IL-15. The cells were engineered for constitutive expression of human CD122 (IL-15Rβ; IL-2Rβ; NM_000878.4), and conditional expression of firefly luciferase driven by STAT5 response elements located upstream of the minimal TATA promoter. Expression of CD122 allows formation of a functional IL-15 receptor at the surface of Jurkat cells, which naturally express high levels of CD132 (also known as IL-15 receptor subunit γc). Activation of the STAT5 signaling pathway in response to IL-15 or IL-15 analogs can be monitored by measuring luciferase activity.

Please note this product may be subject to fees, we invite you to contact your local office. Recombinant THP-1 cells constitutively expressing the firefly (Photinus pyralis) luciferase gene under the control of a CMV promoter.

Please note this product may be subject to fees, we invite you to contact your local office. Recombinant HL-60 cells constitutively expressing the firefly (Photinus pyralis) luciferase gene under the control of a CMV promoter.

Please note this product may be subject to fees, we invite you to contact your local office. Recombinant clonal CHO cell line stably expressing full length human FUT4 (fucosyltransferase 4). Since FUT4 controls the synthesis of antigen CD15, forced expression of FUT4 results in overexpression of CD15 at the cell surface, which was confirmed by flow cytometry. The stable clonal cell line was selected for high levels of CD15 expression compared to the parental CHO-K1 cell line.

Please note this product may be subject to fees, we invite you to contact your local office. Recombinant clonal CHO-K1 cells stably expressing a membrane bound, engineered TCR (T-cell receptor) activator and human FcGR2B (Fc gamma receptor IIb, NM #004001). The cells were generated from the TCR Activator CHO Cell Line (BPS Bioscience #60539).

Please note this product may be subject to fees, we invite you to contact your local office. Recombinant KG-1 cells constitutively expressing the firefly (Photinus pyralis) luciferase reporter gene under the control of a CMV promoter.

Please note this product may be subject to fees, we invite you to contact your local office. Recombinant NALM6 cells constitutively expressing the firefly (Photinus pyralis) luciferase reporter gene under the control of a CMV promoter.

Please note this product may be subject to fees, we invite you to contact your local office. Recombinant CCRF-CEM cells constitutively expressing the firefly (Photinus pyralis) luciferase reporter gene under the control of a CMV promoter.

Please note this product may be subject to fees, we invite you to contact your local office. The CD95 CHO cell line is a recombinant clonal stable CHO cell line constitutively expressing full-length human CD95 receptor (accession number: NM_000043.3). Surface expression of human CD95 was confirmed by flow cytometry. Each clonal cell line was selected for different levels of CD95 expression (High or Medium) to mimic varying CD95 expression levels in cancer cells.

Please note this product may be subject to fees, we invite you to contact your local office. The CD95 CHO cell line is a recombinant clonal stable CHO cell line constitutively expressing full-length human CD95 receptor (accession number: NM_000043.3). Surface expression of human CD95 was confirmed by flow cytometry. Each clonal cell line was selected for different levels of CD95 expression (High or Medium) to mimic varying CD95 expression levels in cancer cells.

Please note this product may be subject to fees, we invite you to contact your local office. Recombinant clonal HEK293 cell line stably expressing full length human CD36. The stable clonal cell line was selected for medium and high levels of CD36 expression compared to the parental HEK293 cell line.

Please note this product may be subject to fees, we invite you to contact your local office. The TCR Knockout Jurkat cell line was generated by CRISPR/Cas9 genome editing to remove the TRAC (T-Cell Receptor Alpha Constant) and TRBC1 (T-Cell Receptor Beta Constant 1) domains of the TCRα and β chains.

Please note this product may be subject to fees, we invite you to contact your local office. B7 homolog 3 protein (B7-H3) CHO Cell line is a recombinant clonal stable CHO cell line expressing full length human B7-H3 protein, also known as cluster of differentiation 276 (CD276, B7H3; B7RP-2; 4Ig-B7-H3). Surface expression of B7-H3 was confirmed by flow cytometry. Each stable clonal cell line was selected for High, Medium, or Low levels of B7-H3 expression to mimic different B7-H3 expression levels in various cancer types.

Please note this product may be subject to fees, we invite you to contact your local office. B7 homolog 3 protein (B7-H3) CHO Cell line is a recombinant clonal stable CHO cell line expressing full length human B7-H3 protein, also known as cluster of differentiation 276 (CD276, B7H3; B7RP-2; 4Ig-B7-H3). Surface expression of B7-H3 was confirmed by flow cytometry. Each stable clonal cell line was selected for High, Medium, or Low levels of B7-H3 expression to mimic different B7-H3 expression levels in various cancer types.

Please note this product may be subject to fees, we invite you to contact your local office. B7 homolog 3 protein (B7-H3) CHO Cell line is a recombinant clonal stable CHO cell line expressing full length human B7-H3 protein, also known as cluster of differentiation 276 (CD276, B7H3; B7RP-2; 4Ig-B7-H3). Surface expression of B7-H3 was confirmed by flow cytometry. Each stable clonal cell line was selected for High, Medium, or Low levels of B7-H3 expression to mimic different B7-H3 expression levels in various cancer types.

Please note this product may be subject to fees, we invite you to contact your local office. The FCGR2A Knockout Jurkat cell line was generated by CRISPR/Cas9 genome editing to remove FCGR2A (CD32A), the gene encoding protein FcγRIIa (Fragment crystallizable gamma receptor II a, also known as FcGRIIa, Fc-gamma-RIIa, and CD32A).

Please note this product may be subject to fees, we invite you to contact your local office. Recombinant CEACAM6 CHO K1 cell line stably expressing the full-length human CEACAM6 receptor (accession number: NM_002483). Surface expression of hCEACAM6 was confirmed by flow cytometry. Each stable clonal cell line was selected for high level of hCEACAM6 expression compared to its parental CHO K1 cells.

Please note this product may be subject to fees, we invite you to contact your local office. This cell line is a double knockout of TCR (T Cell Receptor) and B2M (Beta-2-Microglobulin). First, the TRAC (T-Cell Receptor Alpha Constant) and the TRBC1 (T-Cell Receptor Beta Constant 1) domains of the TCRα/β chains were genetically removed by CRISPR/Cas9 genome editing from Jurkat cells to generate the TCR Knockout Jurkat cell Line (BPS Bioscience #78539). These TCR knockout cells were then used to generate a new cell line in which B2M was also genetically removed by CRISPR/Cas9 genome editing.

Please note this product may be subject to fees, we invite you to contact your local office. This cell line is a double knockout of TCR (T Cell Receptor) and B2M (Beta-2-Microglobulin). First, the TRAC (T-Cell Receptor Alpha Constant) and the TRBC1 (T-Cell Receptor Beta Constant 1) domains of the TCRα/β chains were genetically removed by CRISPR/Cas9 genome editing from NFAT Luciferase Reporter Jurkat cells to generate the TCR Knockout NFAT Luciferase Reporter Jurkat cell Line (BPS Bioscience #78556). These TCR knockout cells were used to generate a new cell line in which B2M was also genetically removed by CRISPR/Cas9 genome editing.  Expression of the firefly luciferase gene is driven by NFAT response elements located upstream of the minimal TATA promoter. Activation of the NFAT signaling pathway in these cells can be monitored by measuring luciferase activity. 

Please note this product may be subject to fees, we invite you to contact your local office. Recombinant Claudin-3 CHO K1 cell line stably expressing the full-length human Claudin-3 (accession number: NM_001306). Surface expression of hClaudin-3 was confirmed by flow cytometry. The stable clonal cell line was selected for high level of hClaudin-3 expression compared to the parental CHO K1 cells.

Please note this product may be subject to fees, we invite you to contact your local office. Recombinant Claudin-4 CHO K1 cell line stably expressing the full-length human Claudin-4 (accession number: NM_001305). Surface expression of hClaudin-4 was confirmed by flow cytometry. Each stable clonal cell line was selected for high level of hClaudin-4 expression compared to the parental CHO K1 cells.

Please note this product may be subject to fees, we invite you to contact your local office. B7-H4 CHO Cell line is a recombinant clonal stable CHO-K1 cell line constitutively expressing full length human B7- H4 protein, also known as V-set domain-containing T-cell activation inhibitor 1 (VTCN1); (NM_024626.4). Surface expression of B7-H4 was confirmed by flow cytometry. Each stable clonal cell line was selected for different levels of B7-H4 expression (Low, Medium and High), to mimic different B7-H4 expression levels in various cancer types.

Please note this product may be subject to fees, we invite you to contact your local office. B7-H4 CHO Cell line is a recombinant clonal stable CHO-K1 cell line constitutively expressing full length human B7- H4 protein, also known as V-set domain-containing T-cell activation inhibitor 1 (VTCN1); (NM_024626.4). Surface expression of B7-H4 was confirmed by flow cytometry. Each stable clonal cell line was selected for different levels of B7-H4 expression (Low, Medium and High), to mimic different B7-H4 expression levels in various cancer types.

Please note this product may be subject to fees, we invite you to contact your local office. B7-H4 CHO Cell line is a recombinant clonal stable CHO-K1 cell line constitutively expressing full length human B7- H4 protein, also known as V-set domain-containing T-cell activation inhibitor 1 (VTCN1); (NM_024626.4). Surface expression of B7-H4 was confirmed by flow cytometry. Each stable clonal cell line was selected for different levels of B7-H4 expression (Low, Medium and High), to mimic different B7-H4 expression levels in various cancer types.

Please note this product may be subject to fees, we invite you to contact your local office. Recombinant K562 cells constitutively expressing firefly (Photinus pyralis) luciferase under the control of a CMV promoter.

Please note this product may be subject to fees, we invite you to contact your local office. Recombinant Raji cells constitutively expressing firefly (Photinus pyralis) luciferase under the control of a CMV promoter.

Please note this product may be subject to fees, we invite you to contact your local office. Recombinant Jurkat T cells expressing both firefly luciferase and enhanced GFP (eGFP) under the control of NFAT response elements located upstream of the minimal TATA promoter. Activation of the NFAT signaling pathway can be monitored by examining either firefly luciferase or eGFP expression.

Please note this product may be subject to fees, we invite you to contact your local office. This cell line was generated from T Cell Receptor (TCR) Knockout NFAT Luciferase Reporter Jurkat Cell Line (BPS Bioscience #78556) by overexpression of human CD8 (NM_001768.6) and NY-ESO-1 TCR (1G4) using lentiviral transduction (CD8a Lentivirus #78648 and NY-ESO-1 -Specific TCR Lentivirus Clone 1G4 #78675). The human TCR clone 1G4 specifically recognizes antigen NY-ESO-1 (New York esophageal squamous cell carcinoma 1).

Please note this product may be subject to fees, we invite you to contact your local office. This cell line was generated from the T Cell Receptor (TCR) Knockout NFAT Luciferase Reporter Jurkat Cell Line (BPS Bioscience #78556) by overexpression of human CD8 (NM_001768.6) and NY-ESO-1 TCR (c259) using lentiviral transduction (CD8a Lentivirus #78648 and NY-ESO-1 -Specific TCR Lentivirus Clone c259 #78676). The human TCR clone c259 that specifically recognizes antigen NY-ESO-1 (New York esophageal squamous cell carcinoma 1). 

Please note this product may be subject to fees, we invite you to contact your local office. This cell line was generated from the T Cell Receptor (TCR) Knockout NFAT Luciferase Reporter Jurkat Cell Line (BPS Bioscience #78556) by overexpression of human CD8 (NM_001768.6) and MART-1-specific TCR (DMF4) using lentiviral transduction (CD8a Lentivirus #78648 and MART-1-Specific TCR Lentivirus Clone DMF4 #78678). The human TCR clone DMF4 specifically recognizes tumor antigen MART-1 (Melanoma-associated antigen recognized by T cells-1, or Melan-A).

Please note this product may be subject to fees, we invite you to contact your local office. Engineered CHO cell line stably expressing human C-terminus MUC16 (CA125) transcript variant 4, from amino acid 13785 to 14507 (NM_024690.2). This portion of MUC16 contains several of the extracellular SEA modules, the transmembrane domain, and the short cytoplasmic tail of the protein. Surface expression of MUC16 was confirmed by flow cytometry. This stable clonal cell line was selected based on its high level of MUC16 expression compared to the parental CHO-K1 cell line.

Please note this product may be subject to fees, we invite you to contact your local office. Recombinant HEK293 cell constitutively expressing full length human GITR. Surface expression is confirmed by flow cytometry.

Please note this product may be subject to fees, we invite you to contact your local office. Recombinant stable clonal CHO cell line constitutively expressing full length human LIGHT protein, also known as TNFSF14, (Genbank #NM_003807). Surface expression is confirmed by flow cytometry.

Please note this product may be subject to fees, we invite you to contact your local office. Recombinant CHO-K1 stably expressing human HVEM (TNF receptor superfamily member 14; TNFRSF14; TR2; ATAR; HVEA; HVEM; CD270; LIGHTR; GenBank Accession #NM_003820).

Please note this product may be subject to fees, we invite you to contact your local office. Recombinant clonal stable Jurkat T cell line expressing firefly luciferase gene under the control of 4 copies of NF-κB response elements with constitutive expression of human HVEM (Herpes Virus Entry Mediator, Tumor Necrosis Factor Receptor Superfamily Member 14, TNFRSF14, CD270, GenBank Accession No. NM_003820). Following activation by human HVEM ligand LIGHT, NF-κB transcription factors bind to the DNA response elements to induce transcription of the luciferase reporter gene. Materials Required but Not Supplied: Assay Medium: Thaw Medium 2 (BPS Cat. #60184) LIGHT, His-Tag (Human) (BPS Cat. #71266 LIGHT-CHO Recombinant Cell Line (BPS Cat. # 79262) 96-well tissue culture-treated white clear-bottom assay plate One-Step luciferase assay system (BPS bioscience # 60690) or other luciferase reagents for measuring firefly luciferase activity Luminometer

Please note this product may be subject to fees, we invite you to contact your local office. Recombinant HEK293 stably expressing human HVEM (Herpesvirus entry mediator; CD270; TNFRSF14; ATAR) GenBank Accession # NM_003820).

Please note this product may be subject to fees, we invite you to contact your local office. Recombinant HEK293 stably expressing human TIGIT (T cell immunoreceptor with Ig and ITIM domains; VSTM3; VSIG9), GenBank Accession #NM_173799.

Please note this product may be subject to fees, we invite you to contact your local office. Adenosine A2a receptor (A2aR or ADORA2A) stably expressed in HEK-293 cells. A2aR is a member of the seven transmembrane G protein-coupled receptor (GPCR) family. The activity of A2aR is mediated by Gs protein which activates adenylyl cyclase, resulting in the synthesis of intracellular cAMP. The level of cAMP correlates with the respective adenosine (agonist) level, and the cell line can be used to measure the EC50 and IC50 values of A2aR agonists or antagonists in a quantitative manner. Binding of extracellular adenosine ligand or its stable analog NECA (5′-(N-Ethylcarboxamido) adenosine) to the A2aR expressed on the surface of this cell line induces cAMP expression.

Please note this product may be subject to fees, we invite you to contact your local office. Recombinant Jurkat T cell expressing firefly luciferase gene under the control of NFAT response elements with constitutive expression of woodchuck (groundhog, Marmota monax) PD-1 (Programmed Cell Death 1, PDCD1, SLEB2, CD279, GenBank Accession #HQ403652).

Please note this product may be subject to fees, we invite you to contact your local office. Recombinant CHO-K1 cells constitutively expressing woodchuck (groundhog, Marmota monax) PD-L1 (Programmed Cell Death 1 Ligand 1, CD274, B7 homolog 1 (B7- H1), GenBank accession # HQ403651) and an engineered T cell receptor (TCR) activator.

Please note this product may be subject to fees, we invite you to contact your local office. Recombinant clonal stable CHO cell line constitutively expressing full length human BCMA protein, also known as TNFRSF17, (Genbank #NM_001192). Surface expression of BCMA was confirmed by flow cytometry.

Please note this product may be subject to fees, we invite you to contact your local office. Recombinant clonal stable CHO cell line constitutively expressing full length human BCMA protein, also known as TNFRSF17, (Genbank #NM_001192). Surface expression of BCMA was confirmed by flow cytometry. Each stable clonal cell line was selected for different levels of BCMA expression, (H. M, L), to mimic different stages of cancer target cells with various BCMA expression levels.

Please note this product may be subject to fees, we invite you to contact your local office. Recombinant Jurkat T cell expressing firefly luciferase gene under the control of NF-kB response elements with constitutive expression of human CD27 (also known as Tumor Necrosis Factor Receptor Superfamily Member 7, TNFRSF7, and T14, Genbank Accession #BC012160)

Please note this product may be subject to fees, we invite you to contact your local office. Recombinant CHO-K1 cells constitutively expressing human CD70 (also known as Tumor Necrosis Factor Ligand Superfamily Member 7, TNFSF7, CD27 Ligand, Ki-24 antigen, CD27-L, and CD27LG; GenBank accession #NM_001252).

Please note this product may be subject to fees, we invite you to contact your local office. Recombinant FcGR2B-CHO K1 cell line stably expressing full length human FcGR2B (isoform 1, GenBank Accession Number NM_004001.4). Crosslinking of antibodies bound to target by FcGR-expression cells can promote receptor clustering and increase downstream signaling. FcGR2B crosslinking is important for anti-TNFR receptor antibodies.

Please note this product may be subject to fees, we invite you to contact your local office. Recombinant Jurkat T cell expressing firefly luciferase gene under the control of IL-2 promoter with constitutive expression of human CTLA4 (Cytotoxic T-Lymphocyte Associated Protein, CD152; GenBank Accession #NM_005214).

Please note this product may be subject to fees, we invite you to contact your local office. Recombinant clonal stable CHO cell line constitutively expressing full length human CD22 protein (Genbank #NM_001771). Surface expression of CD22 was confirmed by flow cytometry. This clonal cell line was selected for medium level expression of CD22. A clone exhibiting higher levels of CD22 expression is also available (#79557-M). Please contact BPS Bioscience for additional information.

Please note this product may be subject to fees, we invite you to contact your local office. Recombinant clonal stable CHO cell line constitutively expressing full length human CD22 protein (Genbank #NM_001771). Surface expression of CD22 was confirmed by flow cytometry. This clonal cell line was selected for medium level expression of CD22. A clone exhibiting higher levels of CD22 expression is also available (#79557-H). Please contact BPS Bioscience for additional information.

Please note this product may be subject to fees, we invite you to contact your local office. Recombinant clonal stable CHO cell line constitutively expressing full length human CD19 protein, also known as B4 or CVID3, (Genbank #NM_001770). Surface expression of CD19 was confirmed by flow cytometry. Each stable clonal cell line was selected for different levels of CD19 expression (High, Medium, Low) to mimic different stages of cancer target cells with various CD19 expression levels.

Please note this product may be subject to fees, we invite you to contact your local office. Recombinant clonal stable CHO cell line constitutively expressing full length human CD19 protein, also known as B4 or CVID3, (Genbank #NM_001770). Surface expression of CD19 was confirmed by flow cytometry. Each stable clonal cell line was selected for different levels of CD19 expression (High, Medium, Low) to mimic different stages of cancer target cells with various CD19 expression levels.

Please note this product may be subject to fees, we invite you to contact your local office. Recombinant clonal stable CHO cell line constitutively expressing full length human CD19 protein, also known as B4 or CVID3, (Genbank #NM_001770). Surface expression of CD19 was confirmed by flow cytometry. Each stable clonal cell line was selected for different levels of CD19 expression (High, Medium, Low) to mimic different stages of cancer target cells with various CD19 expression levels.

Please note this product may be subject to fees, we invite you to contact your local office. Recombinant Jurkat T cell expressing firefly luciferase gene under the control of NFAT response elements with constitutive expression of human CD160. CD160 is a GPIanchored glycoprotein member of the Ig superfamily, also known as BY55, NK1, and NK28. GenBank Accession # NM_007053.

Please note this product may be subject to fees, we invite you to contact your local office. Recombinant CHO-K1 cells constitutively expressing human PD-L2 (Programmed Cell Death 1 Ligand 2 or CD273, GenBank accession #NM_025239) and an engineered T-cell receptor (TCR) activator.

Please note this product may be subject to fees, we invite you to contact your local office. Recombinant CHO-K1 cells constitutively expressing human ICOSL (also known as human secreted B7 homolog 2 (B7-H2), CD275, ICOSLG, and B7-related protein (B7RP), GenBank Accession No. NM_001283050.

Please note this product may be subject to fees, we invite you to contact your local office. Recombinant Jurkat T cell expressing firefly luciferase gene under the control of NFAT response elements with constitutive expression of human PD-1 (Programmed Cell Death 1, PDCD1, SLEB2, CD279, GenBank Accession #NM_005018). Note: These cells are unable to complete mitosis and are suitable for single use assays. For cells capable of reproducing, please use our PD-1 / NFAT Reporter - Jurkat Recombinant Cell Line, #60535.

Please note this product may be subject to fees, we invite you to contact your local office. The mouse ADCC Reporter cells (mFcγRIV /NFAT-Jurkat cells) are recombinant Jurkat T cell expressing firefly luciferase gene under the control of NFAT response elements with constitutive expression of mouse FcγRIV (NM_144559.2).

Please note this product may be subject to fees, we invite you to contact your local office. Recombinant Jurkat cells constitutively expressing human LILRB4 (Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 4, GenBank Accession #NM_001278426) and the firefly luciferase gene under the control of NFAT response elements.

Please note this product may be subject to fees, we invite you to contact your local office. Recombinant Jurkat T cell expressing firefly luciferase gene under the control of NFAT response elements with constitutive expression of mouse PD-1 (Programmed Cell Death 1, PDCD1, SLEB2, CD279, GenBank Accession #NM_008798).

Please note this product may be subject to fees, we invite you to contact your local office. Recombinant CHO-K1 cells constitutively expressing mouse PD-L1 (Programmed Cell Death 1 Ligand 1, CD274, B7 homolog 1 (B7- H1), GenBank accession # NM_021893) and an engineered T cell receptor (TCR) activator.

Please note this product may be subject to fees, we invite you to contact your local office. Recombinant human BAFF-R-CHO K1 cell line stably expressing full length human BAFF-R/TNFRSF13C receptor (GenBank Accession: NM_052945.3). Surface expression of BAFF-R was confirmed by flow cytometry. Each stable clonal cell line was selected for different levels of BAFF-R expression (High, Medium, Low) to mimic different stages of cancer target cells with various BAFF-R expression levels.

Please note this product may be subject to fees, we invite you to contact your local office. Recombinant human BAFF-R-CHO K1 cell line stably expressing full length human BAFF-R/TNFRSF13C receptor (GenBank Accession: NM_052945.3). Surface expression of BAFF-R was confirmed by flow cytometry. Each stable clonal cell line was selected for different levels of BAFF-R expression (High, Medium, Low) to mimic different stages of cancer target cells with various BAFF-R expression levels.

Please note this product may be subject to fees, we invite you to contact your local office. Recombinant human BAFF-R-CHO K1 cell line stably expressing full length human BAFF-R/TNFRSF13C receptor (GenBank Accession: NM_052945.3). Surface expression of BAFF-R was confirmed by flow cytometry. Each stable clonal cell line was selected for different levels of BAFF-R expression (High, Medium, Low) to mimic different stages of cancer target cells with various BAFF-R expression levels.

Please note this product may be subject to fees, we invite you to contact your local office. Recombinant CD33 -CHO K1 cell line stably expressing the full length human C33/Siglec-3 receptor (GenBank Accession: BC028152.1). Surface expression of CD33 was confirmed by flow cytometry. Each stable clonal cell line was selected for different levels of CD33 expression (High, Medium, Low) to mimic different stages of cancer target cells with various CD33 expression levels.

Please note this product may be subject to fees, we invite you to contact your local office. Recombinant CD33 -CHO K1 cell line stably expressing the full length human C33/Siglec-3 receptor (GenBank Accession: BC028152.1). Surface expression of CD33 was confirmed by flow cytometry. Each stable clonal cell line was selected for different levels of CD33 expression (High, Medium, Low) to mimic different stages of cancer target cells with various CD33 expression levels.

Please note this product may be subject to fees, we invite you to contact your local office. Recombinant CD33 -CHO K1 cell line stably expressing the full length human C33/Siglec-3 receptor (GenBank Accession: BC028152.1). Surface expression of CD33 was confirmed by flow cytometry. Each stable clonal cell line was selected for different levels of CD33 expression (High, Medium, Low) to mimic different stages of cancer target cells with various CD33 expression levels.