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ioAstrocytes are functional human iPSC-derived astrocytes, deterministically programmed using opti-ox™ technology that convert consistently into defined astrocytes within days. Cells demonstrate expected stellate morphology, express key astrocytic markers (SOX9, EAAT1, S100B and Vimentin), are capable of phagocytosis, cytokine secretion, and modulation of neuronal activity in co-culture.