Chemicals & Small Molecules

Rubitecan is an orally administered camptothecin that demonstrates anti-tumor efficacy. Reagent grade, for research purpose.

Karenitecin, characterized as a formidable topoisomerase I inhibitor, exhibits robust anti-cancer effects. It instigates DNA damage and elevates the protein expression of cyclin E and cdk2 in A253 cells.

Namitecan has been investigated in clinical trials focused on treating solid tumors. Functioning as a potent inhibitor of topoisomerase I, Namitecan possesses noteworthy antitumor properties. Reagent grade, for research purpose.

Lurtotecan, a semi-synthetic analog of camptothecin, stabilizes the topoisomerase I-DNA complex, inhibiting DNA replication and causing apoptosis through the formation of an enzyme-drug-DNA ternary complex. It also disrupts RNA synthesis, promotes the degradation of topoisomerase I, and alters chromatin structure, making it useful in PROTAC development for targeted cancer treatments.

(S)-4-ethyl-4-hydroxy-7,8-dihydro-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione serves as a versatile building block for complex compounds, offering utility as an intermediate or foundational component for reactions with other chemical compounds. It is also an intermediate of Exatecan. Reagent grade, for research purpose.

N-(8-amino-6-fluoro-5-methyl-1-oxo-1,2,3,4-tetrahydronaphthalen-2-yl)acetamide, alternatively referred to as Exatecan Intermediate 2, serves as a crucial interim component in the synthesis of Exatecan. Exatecan is an anticancer agent classified among the camptothecin analogs.

Aminooxy-PEG4-MMAF is an agent-linker combination designed for antibody-drug conjugates (ADCs), harnessing the robust antitumor efficacy of the potent anti-tubulin agent MMAF. This connection is established through the water-soluble PEG4 linkage. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

N-Boc-dolaproine (Dap) constitutes the amino acid component derived from the pentapeptide Dolastatin 10. Reagent grade, for research purpose.

Boc-Dap-NE, a dipeptide, serves as a detachable linker in the construction of antibody-drug conjugates (ADCs). Reagent grade, for research purpose.