Chemicals & Small Molecules

Fluorescein-PEG2-Biotin is a xanthene dye with excitation/emission maximum of 494/517 nm and a terminal biotin group with hydrophilic PEG spacer arm. The biotin group is effective at binding proteins such as binding to avidin, streptavidin or neutravidin. The hydrophilic PEG spacer can increase aqueous solubility of the biotin conjugated molecules. It also can also help minimize steric hindrance and provide extra flexibility with the binding to stravidin and avidin molecules. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Fmoc-Ala-Ala-Asn is a Fmoc-protected tripeptide linker employed for ADC conjugation. It contains a cleavable Ala-Ala-Asn peptide sequence.

BDP FL-PEG8-DBCO is a BDP FL linker containing a reactive DBCO group and a hydrophilic PEG spacer arm. DBCO reacts with azide-bearing compounds or biomolecules to form a stable triazole linkage without copper catalysts. BDP FL-PEG8-DBCO is a bright and photostable thiol-reactive dye for protein labeling, peptide modification, and can replace fluorescein for microscopy. The hydrophilic PEG spacer arm increases water solubility, membrane permeability, and conjugation efficiency. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

9-Oxoheptadecanedioic acid

Azido-PEG4-Val-Ala-PAB-Exatecan serves as a cathepsin-cleavable Val-Ala dipeptide conjugated to an exatecan payload, a structural analog of camptothecin. The terminal azido partakes in click chemistry reactions with DBCO, BCN, and linear alkynes.

Azido-PEG4-Val-Ala-PAB-SN38 serves as a cleavable ADC linker featuring a cleavable Val-Cit dipeptide, a PAB group, and an SN38 warhead. The PEG linker improves the solubility of the compound. The azide moiety can perform click chemistry reactions with BCN, DBCO, and linear alkynes.

FAM Phosphoramidite, 6-isomer (hydroxyprolinol) serves as a versatile reagent for 5’ and internal labeling of oligonucleotides. It facilitates the synthesis of fluorescein-labeled strands. The 6-aminohexanoate linkage acts as a spacer between the nucleotide skeleton and the functional group. Additionally, this reagent features a dimethoxythrityl protection group, enabling purification via reversed-phase HPLC or cartridge methods.

TCO Phosphoramidite C6 acts as a versatile reagent for TCO-modified oligonucleotides, introducing a TCO moiety into substrates with primary or secondary hydroxyl groups. Trans-cyclooctene readily reacts with tetrazines via inverse electron-demand Diels-Alder cycloaddition (IEDDA). The resulting TCO-Tetrazine ligation offers ultrafast kinetics, selectivity, and long-term stability in aqueous media, making it valuable for low-concentration applications like protein-protein conjugations.

DAPI (hydrochloride) is a blue-emitting fluorescent dye that strongly binds to adenine-thymine-rich regions in DNA. Widely used in fluorescence microscopy and flow cytometry, DAPI serves as a nuclear counterstain. When bound to double-stranded DNA, DAPI exhibits ~20-fold fluorescence enhancement, with an absorption peak at 358 nm and emission peak at 461 nm. It also binds to RNA, albeit with less intensity, causing its emission spectrum to shift to ~500 nm.