Chemicals & Small Molecules

Bromide-Val-Cit-PAB-MMAE is a synthetic antibody-drug conjugate (ADC) coupled to a bromide group, which is a very good leaving group for nucleophilic substitution reactions. It contains a protease-sensitive Val-Cit dipeptide and an MMAE payload, which is a synthetic antineoplastic agent that can be attached to a monoclonal antibody (mAb) for targeting cancer cells. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

nonadeca-1,18-dien-10-ol

BDP FL-PEG8-NHS ester is a BDP dye linker containing a NHS ester group and a hydrophilic PEG spacer arm. The NHS ester allows the dye to react with primary amines and the hydrophilic PEG spacer arm increases water solubility as well as membrane permability. This dye is used for protein and peptide labeing and is photostable. BDP FL-PEG8-NHS ester is a green-fluorescent dye and has several characteristics that make it potentially superior in some applications, including high extinction coefficient, high fluorescence quantum yield, narrow emission bandwidth, red shift in fluorescence emission at high dye concentrations, relatively long excited-state lifetime, etc. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Azide-Val-Cit-PAB-OH functions as a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). The Val-Cit will specifically be cleaved by Cathepsin B. The azide moiety participates in copper-catalyzed Click Chemistry reactions with alkyne, DBCO, and BCN. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Azide-PEG4-Val-Cit-PABC-Exatecan is an enzymatically cleavable linker-payload conjugate, and it can be used in the synthesis of antibody-drug conjugates (ADCs). The Val-Cit will specifically be cleaved by Cathepsin B. Exatecan is a structural analog of camptothecin and shows anticancer activity. The azide group can react with alkyne, BCN, and DBCO via Click Chemistry.

Sulfo TCO-Maleimide is a water-soluble reagent for attaching TCO moieties to cysteine-containing peptides or other thiol-containing molecules. The maleimide group selectively reacts with reduced thiols at pH 6.5-7.5, forming stable thioether bonds. The hydrophilic sulfonated spacer enhances water solubility, and the short spacer arm adds minimal mass to the modified molecules. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Iodoacetamide alkyne is a cysteine-reactive probe that covalently binds cysteine residues in proteins and peptides to an alkyne group. The alkyne can be used in click chemistry to attach fluorophores or biotin, allowing visualization by in-gel fluorescence or identification by mass spectrometry. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Bromoacetamido-PEG12-Tris(-PEG11-bromoacetamide) functions as a branched PEG linker, where the terminal bromo groups are good leaving groups for nucleophilic substitution reactions. The PEG links raise the solubility of the molecule in aqueous media and assist in optimizing DMPK properties. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

MAL-PEG24-amido-PEG24-amido-PEG24-DSPE includes DSPE connected via hydrophilic PEG arms to maleimide, which will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol. The hydrophobic DSPE encapsulates hydrophobic drugs, while the hydrophilic PEG arms improve water solubility for effective drug delivery.