Chemicals & Small Molecules

Azide-PEG4-Val-Cit-PAB-SN-38 serves as a cleavable ADC linker conjugated to SN-38, an anti-tumor drug and active metabolite of irinotecan. SN-38 inhibits DNA topoisomerase I, halting DNA synthesis and causing single-strand breaks. The Val-Cit linker is cleaved by lysosomal Cathepsin B, ensuring targeted intracellular release. The azide group participates in copper-catalyzed click chemistry with alkyne, DBCO, and BCN. The PEG spacer imparts water solubility to the molecule and helps optimize DMPK properties.

PC-PEG3-biotin functions as a biotinylating reagent featuring a photocleavable moiety and terminal biotin which can react with amine molecules in the presence of activators like EDC or HATU. This structure allows for efficient photorelease of linked molecules, typically achieving over 90% cleavage in 5-25 minutes using a near-UV lamp. The PEG3 spacer imparts hydrophilicity. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

AMCA-PEG1-amide-PEG4-Azide is a fluroescent reagent with an azide group for click chemistry conjugation with terminal alkynes via a copper-catalyzed click reaction or strained cyclooctynes via a copper-free click reaction. The hydrophilic PEG spacer arm increases water solubility, membrane permability, and conjugation efficiency. The additional amide bond could potentially introduce the hydrogen bonding and beneficial some specific applications. AMCA-PEG1-amide-PEG4-Azide is a popular blue fluorescent tagging molecule that has a maximal absorption of 345 nm and emission at 450 nm. This dye is used for protein and peptide labeing. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

AMCA-PEG4-Azide is a fluroescent reagent with an azide group for click chemistry conjugation with terminal alkynes via a copper-catalyzed click reaction or strained cyclooctynes via a copper-free click reaction. The hydrophilic PEG spacer arm increases water solubility, membrane permability, and conjugation efficiency. AMCA-PEG4-Azide is a popular blue fluorescent tagging molecule that has a maximal absorption of 345 nm and emission at 450 nm. This dye is used for protein and peptide labeing. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

3,4-Dibromo-Mal-PEG8-Boc-Amine functions as a site-specific ADC linker with a dibromomaleimide group and boc-protected amine that can be hydrolyzed under acidic conditions to produce a free amine which is reactive to an activated succinimidyl (NHS) ester. The dibromomaleimide group allows for two points of substitution due to the two bromine atoms. Dibromo-Maleimide is sensitive to high temperature and light. The hydrophilic PEG8 spacer improves the aqueous solubility of the compound and aids in optimizing DMPK properties. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Methyl palmitoleate

BDP FL-PEG3-Methyltetrazine is a BDP dye linker containing a methyltetrazine group and a hydrophilic PEG spacer arm. Methyltetrazine is reactive toward trans-cyclooctenes. The additional methyl on the methyltetrazine enhances the stability of the group. The hydrophilic PEG spacer arm increases water solubility, membrane permability, and conjugation efficiency. This dye is used for protein and peptide labeing and is photostable. BDP FL-PEG3-Methyltetrazine is a green-fluorescent dye and has several characteristics that make it potentially superior in some applications, including high extinction coefficient, high fluorescence quantum yield, narrow emission bandwidth, red shift in fluorescence emission at high dye concentrations, relatively long excited-state lifetime, etc. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

BDP FL-PEG4-DBCO is a fluorescent reagent containing a reactive DBCO group and a hydrophilic PEG spacer arm. DBCO reacts with azide-bearing compounds or biomolecules to form a stable triazole linkage without copper catalysts and the hydrophilic PEG spacer arm increases water solubility as well as membrane permability. This dye is used for protein and peptide labeing and is photostable. BDP FL-PEG4-DBCO is a green-fluorescent dye and has several characteristics that make it potentially superior in some applications, including high extinction coefficient, high fluorescence quantum yield, narrow emission bandwidth, red shift in fluorescence emission at high dye concentrations, relatively long excited-state lifetime, etc. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

BP Lipid 427 is a symmetric polar lipid featuring a two branched tails and a hydroxyl group. This compound may be used for bioconjugation and surface modification applications, or as a useful synthetic scaffold for novel lipids. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.