Chemicals & Small Molecules

DLG-PEG 2000 (18:2)

AMCA-PEG4-Amine, TFA salt is a AMCA dye linker containing an amine group and a hydrophilic PEG spacer arm. The amine group makes the compound more reactive toward carboxylic acids, NHS esters and other carbonyl groups. The hydrophilic PEG spacer arm increases water solubility as well as membrane permability. This dye is used for protein and peptide labeing. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Mal-PEG8-Val-Ala-PAB is an ADC linker with a Val-Ala dipeptide that can be cleaved by Cathepsin B and Maleimide (Mal) group that is reactive toward thiol groups. The PEG8 chain enhances the water-solubility of the molecule and assists in fine-tuning DMPK properties.

bis-DBCO-PEG. MW 20,000 is a homobifunctional PEG polymer possessing two terminal DBCO moieties. DBCO will react with azide-containing compounds or biomolecules to form a stable triazole linkage without a copper catalyst. The 20k PEG units elevate the solubility of the compound in aqueous media.

Fluorescein-PEG12-(N-Boc)-Amine is a heterobiofunctional PEG linker containing a fluorescein dye and a Boc-protected amine group, which can be regenerated by mild acidic conditions and then be reactive with cabroxylic acid, activated NHS ester, carbonyl (ketone, aldehyde) etc. Fluorescein is a common fluorescent tracer (494nm/521nm) for staining cells, tissues, biomarkers or nanoparticles and this reagent can be used to tag biomolecules and nanoparticles. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Sulfo DBCO-UBQ-2 is a click chemistry reagent combining a dark quencher, UBQ-2, with a polyaromatic-azo backbone, offering no native emission. It effectively quenches fluorescence in the 560-670 nm range, ideal for qPCR probes and FRET applications with orange to far-red dyes. The DBCO group participates in copper-free click chemistry, while the sulfo group enhances water solubility.

UBQ-1 is a dark quencher with a polyaromatic-azo backbone, exhibiting no native emission. It quenches fluorescence in the 480-580 nm range, making it ideal for qPCR probes and FRET applications with green to yellow dyes like FAM, Oregon Green®, TET, JOE, HEX, Alexa Fluor® 488, and DyLight® 488.

Sulfo DBCO-UBQ-1 serves as a click chemistry reagent uniting UBQ-1, which is a dark quencher with a polyaromatic-azo backbone that exhibits no native emission, with a sulfo group for improved hydrophilicity and DBCO for undergoing copper-free click chemistry.

(+)-JQ-1-PEG4-Amido-N-t-Boc possesses a Boc-protected amino (NH2) group, which is reactive with activated NHS esters or carboxylic acid in the presence of EDC or HATU, and (+)-JQ-1, which functions as a potent, specific, and reversible pan-BET (bromodomain and extra-terminal motif) family inhibitor. t-Boc-aminooxy can be deprotected under mild acidic conditions. (+)-JQ-1 can be a useful chemical probe to investigate the role of BET bromodomains in the transcriptional regulation of oncogenesis. The PEG4 spacer bolsters hydrophilicity.