Chemicals & Small Molecules

5-Sulfosalicylic acid, a sulfonated salicylic acid derivative, is effective against breast cancer cell lines with less toxicity [1] and possesses antioxidant activities [2].

800CW NHS ester is a near-infrared probe used for labeling lysine residues (λ max = 776 nm) [1][2].

Ac4ManNDAz serves as a cell-permeable photocross-linking probe that competes effectively with endogenous sialic acid to incorporate into cell surface glycoproteins. Upon exposure to UV light, it forms cross-links with glycoprotein ligands. This compound is particularly useful for studying interactions between glycoproteins [1].

ACBI3 is a selective pan-KRAS degrader with anticancer activity that degrades oncogenic KRAS. ACBI3 inhibits the growth of most cancer cell lines driven by KRAS mutations.

Antiproliferative agent-22 is an anticancer compound that shows antiproliferative activity on MCF-7, MDA-MB-231, and MDA-MB-468 cells.Antiproliferative agent-22 is used in cancer research.

Celestine Blue is an electroactive indicator in DNA biosensors, strongly adsorbed on spinel phases and CNT (carbon nanotubes), facilitating dispersion, acting as a capping agent, and enabling the fabrication of spinel-decorated CNT. It is an efficient charge transfer mediator, significantly improving capacitive behavior. TiO2 nanoparticles doped with Celestine Blue can be used as a label in a sandwich immunoassay for the hepatitis C virus (HCV) core antigen [1] [2] [3].

Cyanine 3.5 (Cy3.5 NHS ester) chloride, a red fluorescent dye and reactive Cy3.5 fluorophore analog, is utilized for the labeling of amino groups in peptides, proteins, and oligonucleotides. It exhibits an excitation wavelength (λ ex) of 591 nm and an emission wavelength (λ em) of 604 nm. [1] [2]

DAPM, a Notch pathway inhibitor, exhibits anticancer activity and antiproliferative effects. It effectively suppresses tubular adenoma development by inhibiting cell proliferation and inducing the expression of Krüppel-like factor 4 (KLF4) and p21 in human colon cancer cells [1].

ELOVL6-IN-4 is a potent and selective long chain fatty acid elongase 6 (ELOVL6) inhibitor that is orally active, with IC50 values of 79 nM for human ELOVL6 and 94 nM for mouse ELOVL6. It demonstrates excellent selectivity over other human ELOVL subtypes (ELOVL1, -2, -3, and -5) and mouse ELOVL3 [1].